{"title":"p53","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout P53:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003ep53 is one of the most well-known tumor suppressor genes. In addition, recent research has found that p53 can be used to diagnose cancer, and it may have a role in inhibiting cancer progression.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMechanism of p53\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe protein p53 is primarily known for its tumor suppression function.\u003cbr data-mce-fragment=\"1\"\u003ep53 can either induce cell cycle arrest or apoptosis and halt the spread of cancerous cells. The way it does this is by inactivating negative regulators of the cell such as MDM-II, which activates caspases to disrupt mitochondrial membrane potential (MMPD), and CDK, which is necessary for the synthesis of DNA. This action leads to either apocr cell cycle arrest (not mitosis).\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eStructure of p53\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eProtein 53 has an N-terminal domain composed of two alpha-helices with a dimerization interface that binds six zinc ions at Zn-II, Zn-III, and Zn-IV. T\u003cbr data-mce-fragment=\"1\"\u003eThis domain is predominantly hydrophobic, with many leucine residues that are likely crucial for the protein's function.\u003cbr data-mce-fragment=\"1\"\u003eThe C-terminal domain has two functional parts: TADs and zinc fingers. The stretch between amino acids 216 to 363 comprises the TADs.\u003cbr data-mce-fragment=\"1\"\u003eIn the human protein, these domains are 79 amino acid residues with a molecular weight of approximately 25 kDa and an isoelectric point (pI) at pH 11.\u003cbr data-mce-fragment=\"1\"\u003eThe zinc fingers are essential for DNA binding as they bind four zinc ions each to form dimers that bind to DNA.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eFunctions of p53\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003ep53 has the following functions:\u003cbr data-mce-fragment=\"1\"\u003e●It is a tumor suppressor gene that can halt the spread of cancerous cells.\u003cbr data-mce-fragment=\"1\"\u003e●It regulates cellular response to stress, such as oxidative stress or genotoxic stresses, for example, when exposed to DNA-damaging agents like UV light or ionizing radiation.\u003cbr data-mce-fragment=\"1\"\u003eIn conclusion, p53 is an important tumor suppressor gene that can be used to diagnose cancer and may have a role in inhibiting cancer progression.\u003c\/p\u003e","products":[{"product_id":"p53-human-gst","title":"p53 Human","description":"\u003cp\u003ep53 Protein Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCellular tumor antigen p53, Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13, TP53, P53, LFS1, TRP53, FLJ92943.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174467469396,"sku":"PRO-742","price":175.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174467502164,"sku":"PRO-742","price":270.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174467534932,"sku":"PRO-742","price":490.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-p53-human-gst-PRO-742.png?v=1776704650"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_41e75fd8-64f0-44d5-bbe9-3e8d77b3cc63.png?v=1700647739","url":"https:\/\/prospecbio.com\/collections\/p53.oembed","provider":"prospecbio","version":"1.0","type":"link"}