{"title":"Neurotrophic factors","description":"\u003ch3 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout Neurotrophic Factors:\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp data-mce-fragment=\"1\"\u003eA family of biomolecules; Neurotrophic Factors (NTFS) consist mainly of small proteins and peptides, which include Nerve Growth Factor (NGF), glial cell line–derived neurotrophic factor (GDNF) family ligands, brain-derived neurotrophic factor (BNDF), and neuropoietic cytokines; which are essential to the differentiation, survival, and growth of neurons in all stages of development. Neurotrophic Factors promote the development and initial growth of neurons in both nervous systems; the central nervous system and the peripheral nervous systems. They have been found able to regenerate and repair neurons that were damaged or faulty both in lab experiments (test tube models) as well as animals.\u003cbr data-mce-fragment=\"1\"\u003eAs well as regenerative effects, and helping with growth, Neurotrophic Factors promote survival of neurons, induce synaptic plasticity, and help to regulate and modulate the creation of the long-term memory. They have also been linked to having a potentially strong role in the treatment of neurodegenerative diseases such as MS.\u003cbr data-mce-fragment=\"1\"\u003eThey also act as survival factors, and ensure that there is a constant equilibrium between the amount of surviving neurons and the appropriate target innervation. They also serve a vital role in regulating and making decisions around cell fate, dendrite pruning, the patterning of innervation, as well as axon growth and the creation of the proteins vital for continued normal function of ion channels and neurotransmitters, as well as other neuronal function.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eNeurotrophic Factors structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eEach Neurotrophic Factor has a slightly different structure, and can be specifically researched; for example, the three-dimensional structure of NGF (Nerve Growth Factor) has been studied and documented, and there is ongoing research into the crystal structures of BNDF (Brain-derived Neurotrophic Factor), as well as others we haven’t mentioned here; NT-4 (Neurotrophin-4) and NT-3 (Neurotrophin-3).\u003cbr data-mce-fragment=\"1\"\u003eAnother example of Neurotrophic structure can be explored in NT-3; which has a unique receptor (TrkC). NT-3 is therefore unique amongst Neurotrophic Factors, despite sharing similar properties, and still being considered important to neuronal survival.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eNeurotrophic Factors location and functions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eAs expected, Neurotrophic Factors are found throughout both nervous systems, and are therefore in all areas of the human body. NT-3 for example is found specifically in the intestinal epithelium, spleen, and thymus; but scientists have thus far been unable to determine its function.\u003cbr data-mce-fragment=\"1\"\u003eOne Neurotrophic Factor that there is more known about is Brain-derived Neurotrophic Factor (BDNF). This is similar in structure to NGF, NT-3 and NT-4 \/ NT-5, and shares the TrkB receptor with NT-4. Scientists know this to promote thymocyte survival, as observed in rodent’s thymus. Moreover, BDHF promotes survival of dorsal root ganglion neurons, and even when it has been bound to truncated forms of TrkB, it shows strong developmental roles. It is therefore essential to survival and neuron development; so much so that when removed from rodents in scientific studies, the mice did not live longer than 3 weeks.\u003cbr data-mce-fragment=\"1\"\u003eOne final function of BDNF is important regulatory roles in the hippocampus; the part of the brain responsible for temporal location, and our navigation. Low BDNF and other Neurotrophic Factor levels have also been seen in patients with untreated depression, but this is controversial, and still under dispute.\u003c\/p\u003e","products":[{"product_id":"nnt1-human","title":"CLCF1 Human","description":"\u003cp\u003eNeurotrophin-1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCardiotrophin-Like Cytokine Factor 1, Novel Neurotrophin-1 , BSF3, CLC, CRLF1 Associated Cytokine-Like Factor 1, B-Cell Stimulating Factor 3, B-Cell-Stimulating Factor 3, BSF-3, NNT-1, NNT1, Neurotrophin-1\/B-Cell Stimulating Factor-3, Cold-Induced Sweating Syndrome 2, B-Cell Stimulatory Factor 3, CISS2, NR6, CLCF1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174294552660,"sku":"CYT-869","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174294585428,"sku":"CYT-869","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174294618196,"sku":"CYT-869","price":4680.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-nnt1-human-CYT-869.png?v=1776703564"},{"product_id":"neurotrophin-3-human","title":"NT 3 Human","description":"\u003cp\u003eNeurotrophin-3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eNeurotrophic factor, Nerve growth factor-2, NGF-2, HDNF, NT-3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174343737428,"sku":"CYT-257","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174343770196,"sku":"CYT-257","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174343802964,"sku":"CYT-257","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-neurotrophin-3-human-CYT-257.png?v=1776703178"},{"product_id":"neurotrophin-3-mouse","title":"NT 3 Mouse","description":"\u003cp\u003eNeurotrophin-3 Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eNeurotrophic factor, Nerve growth factor-2, NGF-2, HDNF, NT-3, Neurotrophin-3, Ntf3, Ntf-3, AI316846, AI835689, Nt3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174344753236,"sku":"CYT-688","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174344786004,"sku":"CYT-688","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174344818772,"sku":"CYT-688","price":4680.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-neurotrophin-3-mouse-CYT-688.png?v=1776703183"},{"product_id":"nt-4-human","title":"NT 4 Human","description":"\u003cp\u003eNeurotrophin-4 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eNT4, NT5, NTF5, NT-4\/5, NTF4, Neurotrophin-4, Neutrophic factor 4, Neurotrophin-5, NT-5.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174346915924,"sku":"CYT-626","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174346948692,"sku":"CYT-626","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174346981460,"sku":"CYT-626","price":4680.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-nt-4-human-CYT-626.png?v=1776703909"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_b2a88319-217b-4f2c-87ab-7217e5011a79.png?v=1700647706","url":"https:\/\/prospecbio.com\/collections\/neurotrophic-factors.oembed","provider":"prospecbio","version":"1.0","type":"link"}