{"title":"NECTIN","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout NECTIN:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe NECTIN Protein is a family of cell-adhesion molecules that, so far, includes four members. They contribute to a wide range of tissue adhesive roles, particularly with the chemical synapse of neurological tissue and the adherents junction of epithelia.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eNECTIN Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe family of molecules will primarily regulate adhesion between two cells, although Nectin-like molecules - known as Necl - will perform other tasks at a cellular level.\u003cbr data-mce-fragment=\"1\"\u003eSome mutations of the gene have been found responsible for a cleft lip or cleft palate, as the gene is required (although not essential) for fusing palatal shelves. Other variants of the gene have been identified, but the nature is yet to be fully uncovered.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eNECTIN Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eOne of the most important interactions that Nectin proteins engage in is with the platelet-derived growth factor receptor (PDGF), as this encourages tissue development and regeneration. It can also interact with other members of the family.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eNECTIN Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eNectin proteins have been identified as providing a wide range of functions within the cell. These include cell movement and proliferation. There is also evidence of differentiation, polarization, and cellular survival. Finally, nectin proteins perform cell-to-cell adhesion.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eNECTIN Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eEach of the four discovered nectins boast the same fundamental structure which is highlighted by three extracellular immunoglobulin domains. Besides these domains, there is also one transmembrane helix and an intracellular domain. The intracellular domain enables the protein to bind a scaffold protein known as adafin.\u003cbr data-mce-fragment=\"1\"\u003eAll nectins are capable of forming homo-cis dimers so that two similar molecules exist on the same membrane. After homo-dimer formation, they can interact in a heterophilic or homophilic manner. In recent reports, there is evidence that heterophilic interactions are more successful than homophilic counterparts.\u003c\/p\u003e","products":[{"product_id":"nectin1-human","title":"NECTIN1 Human","description":"\u003cp\u003eNectin Cell Adhesion Molecule 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003ePVRL1, CD111, CLPED1, ED4, HIgR, HVIS, HVEC, Nectin-1, OFC7, PRR, PRR1, PVRR, PVRR1, SK-12.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174225543252,"sku":"PRO-2648","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174225576020,"sku":"PRO-2648","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174225608788,"sku":"PRO-2648","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-nectin1-human-PRO-2648.png?v=1776703109"},{"product_id":"nectin3-human","title":"NECTIN3 Human","description":"\u003cp\u003eNectin Cell Adhesion Molecule 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eNectin-3, CDw113, Nectin cell adhesion molecule 3, Poliovirus receptor-related protein 3, CD113, PVRL3, PRR3, NECTIN-3, PVRR3, PPR3. \u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174227443796,"sku":"PRO-2504","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174227476564,"sku":"PRO-2504","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174227509332,"sku":"PRO-2504","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-nectin3-human-PRO-2504.png?v=1776703118"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_57209bc9-a5df-470b-abcb-e810042aa6ca.png?v=1700647695","url":"https:\/\/prospecbio.com\/collections\/nectin.oembed","provider":"prospecbio","version":"1.0","type":"link"}