{"title":"MHC class I chain-related gene","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout MIC \/ MHC Class I Chain-related Gene:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eMHC class 1 is a polymorphic cell and encodes a stress-inducible protein chain to meditate intracellular antigens' recognition. MHC class 1, encoded as MICA, translates to a 383-amino acid polypeptide. It’s further known for its unique exon-intron preferential and organization expression.\u003cbr data-mce-fragment=\"1\"\u003eMICA occurs on platelets but is not observed in red blood cells. The functionality of the gene is to display peptide fragments within the cytotoxic T cells.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMIC Molecular Genetics\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe sequence of MICA chains suggests that it folds like Class I chains and might have a capacity to bind short ligands or peptides. Therefore, MICA is predicted to have a significant sequence of the genomic clone.\u003cbr data-mce-fragment=\"1\"\u003eThe MICB and MICA genes are polymorphic, and they display an unusual distribution of amino acids in their extracellular.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMHC Class I Chain-related Gene Expression\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eMICA expression can be unregulated by exposure of the cells to a DNA damaging condition or heat shock. In addition, the expression can get affected by infectious agents, such as diarrheagenic E-coli, human cytomegalovirus, and HPV (human papillomavirus.\u003cbr data-mce-fragment=\"1\"\u003eIn normal tissues, the expression of MICA is intracellularly, with a tiny fraction that appears on the same surface. However, there is no MICA’s expression in the central nervous system\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMIC Functionality\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eEngagement of MICA-NKG2D leads to activation of NK cells and cytolytic responses against tumor cells and other stressed cells. Tumor cells are, however, able to avoid recognition of MHC Class I by the immune system.\u003cbr data-mce-fragment=\"1\"\u003eExcess levels of MICA in the tumor cells are positively associated with poor prognosis and tumor size.\u003cbr data-mce-fragment=\"1\"\u003ePsoriatic arthritis and psoriasis are associated with different variations in the MICA gene.\u003c\/p\u003e","products":[{"product_id":"mic-a-human","title":"MICA Human","description":"\u003cp\u003eMHC Class-I chain related gene A Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eMHC class I polypeptide-related sequence A, MIC-A, MICA, PERB11.1, HLA-B, AS, HLAB, HLAC, SPDA1, HLA-B73, HLA-B-7301.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43173947801684,"sku":"PRO-367","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43173947834452,"sku":"PRO-367","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43173947867220,"sku":"PRO-367","price":4080.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-mic-a-human-PRO-367.png?v=1776443907"},{"product_id":"mica-human-his","title":"MICA Human, His","description":"\u003cp\u003eMHC class I chain-related gene A, Human Recombinant  His Tag\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eMHC class I polypeptide-related sequence A, MIC-A, MICA, PERB11.1, HLA-B, AS, HLAB, HLAC, SPDA1, HLA-B73, HLA-B-7301.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43173948686420,"sku":"PRO-2207","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43173948719188,"sku":"PRO-2207","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43173948751956,"sku":"PRO-2207","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-mica-human-his-PRO-2207.png?v=1776443916"},{"product_id":"mic-b-human","title":"MICB Human","description":"\u003cp\u003eMHC Class-I chain related gene B Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eMHC class I polypeptide-related sequence B, MIC-B, MICB, PERB11.2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43173949505620,"sku":"PRO-368","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43173949538388,"sku":"PRO-368","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43173949571156,"sku":"PRO-368","price":4080.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-mic-b-human-PRO-368.png?v=1776443912"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_e9f8eea2-3038-43d6-a621-bab7c2a75ea8.png?v=1700647653","url":"https:\/\/prospecbio.com\/collections\/mhc-class-i-chain-related-gene.oembed","provider":"prospecbio","version":"1.0","type":"link"}