{"title":"Methylmalonic Aciduria","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout Methylmalonic Aciduria:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eMethylmalonic aciduria is also known as methylmalonic acidemia. It is an inherited disorder that makes your body unable to process some proteins. The diseases manifest themselves between the ages of 1 month to 12 months. Its effects range from mild to severe when the proteins are not broken; instead, they build up, affecting the liver, kidneys, brain and other organs of the patient.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMethylmalonic Aciduria Symptoms\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eVomiting, Slow development, Dehydration, Extreme tiredness, and poor feeding.\u003cbr data-mce-fragment=\"1\"\u003eDelayed treatment may cause the patient to get into a coma and, in the extreme, may cause death.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMethylmalonic Aciduria Causes\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eMethylmalonic aciduria is caused by mutation of MMAA, MMADHC, MMUT, MMACHC, MCEE, and MMAB.\u003cbr data-mce-fragment=\"1\"\u003eA higher percentage of MMA cases are a result of mutation of the MMUT gene. Mutation of this gene prevents the release of functional enzymes resulting in two conditions; the less severe mut form and the mut0 form, which is more severe.\u003cbr data-mce-fragment=\"1\"\u003eThe methylmalonic CoA mutase to function well requires proteins produced by MMAA, MMAB, and MMADHC.\u003cbr data-mce-fragment=\"1\"\u003eTo Find out Whether a Patient Has MMA, several tests have to be carried out and also to determine the extent of the effects on the patient.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMethylmalonic Aciduria Treatment\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eScreening of newborns can tell whether a child has MMA.\u003cbr data-mce-fragment=\"1\"\u003eThe degree of C3 acylcarnitine indicates a positive result of the disorder. However, if several other tests are done, it should show an elevation in methyl citrate and methylmalonic acid.\u003cbr data-mce-fragment=\"1\"\u003eTo treat MMA, a strict protein diet with a supplement of PA – precursor amino acid.\u003c\/p\u003e","products":[{"product_id":"mmachc-human","title":"MMACHC Human","description":"\u003cp\u003eMethylmalonic Aciduria cblC type, with Homocystinuria Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eMethylmalonic aciduria and homocystinuria type C protein, MMACHC, cblC, RP11-291L19.3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174000197716,"sku":"PRO-1119","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174000230484,"sku":"PRO-1119","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174000263252,"sku":"PRO-1119","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-mmachc-human-PRO-1119.png?v=1776702639"},{"product_id":"mmadhc-human","title":"MMADHC Human","description":"\u003cp\u003eMethylmalonic Aciduria cblD type, with Homocystinuria Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eChromosome 2 Open Reading Frame 25, Methylmalonic Aciduria (Cobalamin Deficiency) CblD Type With Homocystinuria, Methylmalonic Aciduria And Homocystinuria Type D Protein Mitochondrial, Protein C2orf25 Mitochondrial, CL25022, C2orf25, cblD.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174001246292,"sku":"PRO-1850","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174001279060,"sku":"PRO-1850","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174001311828,"sku":"PRO-1850","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-mmadhc-human-PRO-1850.png?v=1776702644"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_bdf4a833-fc3c-401e-8d60-4b5bad3fc043.png?v=1700647659","url":"https:\/\/prospecbio.com\/collections\/methylmalonic-aciduria.oembed","provider":"prospecbio","version":"1.0","type":"link"}