{"title":"Mesoderm Development Candidate","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout MESDC \/ Mesoderm Development Candidate:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe Mesoderm Development Candidate 2, professionally known as the MESD (Mesoderm Development LRP Chaperone), is a protein encoded in the MESDC gene in Homo sapiens. This gene concentrates in the thyroid, placenta, and adrenal more than any other tissue in the human body.\u003cbr data-mce-fragment=\"1\"\u003eThe gene goes by many aliases in the medical field. They include KIAA0081, BOCA, OI20, MESD, and Renal Carcinoma Antigen NY-REN-61. It also has related pathways are the Wnt, Hedgehog, and Notch. Moreover, this gene is associated with various diseases in the human body, including Epilepsy, Nocturnal Frontal Lobe, and Type Xx.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMESDC Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe MESD gene occurs in many species, including Primates and Chordata. The gene has 234 amino acids, a molecular mass of 2607 Da, and a quaternary structure.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMesoderm Development Candidate Functions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eMesoderm Development Protein Candidate has various functions on protein coding.\u003cbr data-mce-fragment=\"1\"\u003eFirstly, MESD assists the beta-propeller\/EGF modules in folding within the family of low-density lipoprotein receptors (LPLTs).\u003cbr data-mce-fragment=\"1\"\u003eSecondly, it acts as a modulator of the Wnt pathway by guiding the receptors of this canonical pathway, the LRP5, and LRP6, to the plasma membrane.\u003cbr data-mce-fragment=\"1\"\u003eThirdly, this gene is vital when specifying embryonic polarity and mesoderm induction.\u003cbr data-mce-fragment=\"1\"\u003eLast but not least, MESD holds a fundamental role in neuromuscular junction (MNJ) formation through promoting cell-surface expression of the LRP4. Sometimes, it May regulate the phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMESDC Interaction\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eMESDC2 is a monomer that interacts with LRP5 to form aggregates and chaperones LRP6 to the plasma membrane. Moreover, it interacts with LPR6 to prevent it from forming aggregates and chaperones for its plasma membrane.\u003cbr data-mce-fragment=\"1\"\u003eFinally, MESDC2 interacts with LRP4 to promote glycosylation of LRP4 cells-surface expansion.\u003c\/p\u003e","products":[{"product_id":"mesdc1-human","title":"MESDC1 Human","description":"\u003cp\u003eMesoderm Development Candidate 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eMesoderm Development Candidate 1, MESDC1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43173911396436,"sku":"PRO-1950","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43173911429204,"sku":"PRO-1950","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43173911461972,"sku":"PRO-1950","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-mesdc1-human-PRO-1950.png?v=1776443748"},{"product_id":"mesdc2-human","title":"MESDC2 Human","description":"\u003cp\u003eMesoderm Development Candidate 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eLDLR chaperone MESD, Mesoderm development candidate 2, Mesoderm development protein, Renal carcinoma antigen NY-REN-61, MESDC2, KIAA0081, MESD, BOCA.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43173912346708,"sku":"PRO-122","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43173912379476,"sku":"PRO-122","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43173912412244,"sku":"PRO-122","price":3600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-mesdc2-human-PRO-122.png?v=1776443753"},{"product_id":"mesdc2-mouse","title":"MESDC2 Mouse","description":"\u003cp\u003eMesoderm Development Candidate 2 Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eLDLR\nchaperone MESD, Mesoderm development candidate 2, Mesoderm development protein,\nMesdc2, Mesd.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43173913133140,"sku":"PRO-2260","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43173913165908,"sku":"PRO-2260","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43173913198676,"sku":"PRO-2260","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-mesdc2-mouse-PRO-2260.png?v=1776443758"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_9a9d3d14-4393-47bf-a199-063c860e83f1.png?v=1700647646","url":"https:\/\/prospecbio.com\/collections\/mesoderm-development-candidate.oembed","provider":"prospecbio","version":"1.0","type":"link"}