{"title":"Mediator Complex","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout MED \/ Mediator Complex:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eA multiprotein complex, the Mediator is one that functions in all eukaryotes as a transcriptional coactivator. It was discovered in Roger D. Kornberg’s laboratory in 1990.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMED Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eMediator complexes interact with RNA polymerase II and transcription factors. The chief function of mediator complexes is transmitting signals to the polymerase from the transcription factors.\u003cbr data-mce-fragment=\"1\"\u003eIt is possible for individual sub units to be replaced by different sub units under certain conditions. They could also be absent under specific circumstances as well.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMediator Complex Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eIn addition to this, there are a lot of different regions within mediator proteins that are disordered intrinsically. This may end up contributing to the conformational flexibility that we see both without and with other protein complexes or bound proteins.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMED Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eFor the successful transcription by RNA polymerase II, mediator complex is needed. Mediator has also been proven to make contacts in the transcription preinitiation complex with the polymerase.\u003c\/p\u003e","products":[{"product_id":"med20-human","title":"MED20 Human","description":"\u003cp\u003eMediator Complex Subunit 20 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eMediator of RNA polymerase II transcription subunit 20, Mediator complex subunit 20, TRF-proximal protein homolog, hTRFP, MED20, TRFP, PRO0213.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175217987668,"sku":"PRO-1204","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175218020436,"sku":"PRO-1204","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175218053204,"sku":"PRO-1204","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-med20-human-PRO-1204.png?v=1776702587"},{"product_id":"med21-human","title":"MED21 Human","description":"\u003cp\u003eMediator Complex Subunit 21 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSRB7, SURB7, Mediator complex subunit 21, RNA polymerase II holoenzyme component SRB7, hSrb7.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175219036244,"sku":"PRO-1476","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175219069012,"sku":"PRO-1476","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175219101780,"sku":"PRO-1476","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-med21-human-PRO-1476.png?v=1776702592"},{"product_id":"med27-human","title":"MED27 Human","description":"\u003cp\u003eMediator Complex Subunit 27 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eMediator Complex Subunit 27, MED27, CRSP8, Cofactor Required For Sp1 Transcriptional Activation, Subunit 8 34kDa, P37 TRAP\/SMCC\/PC2 Subunit, Transcriptional Coactivator CRSP34, CRSP34, CRSP Complex Subunit 8, CRAP34, TRAP37, Mediator of RNA Polymerase II Transcription Subunit 27, Cofactor Required For Sp1 Transcriptional Activation Subunit 8.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175220019284,"sku":"PRO-1946","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175220052052,"sku":"PRO-1946","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175220084820,"sku":"PRO-1946","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-med27-human-PRO-1946.png?v=1776702599"},{"product_id":"med4-human","title":"MED4 Human","description":"\u003cp\u003eMediator Complex Subunit 4 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eMediator of RNA polymerase II transcription subunit 4, Mediator complex subunit 4, Vitamin D3 receptor-interacting protein complex 36 kDa component, Activator-recruited cofactor 36 kDa component, TRAP\/SMCC\/PC2 subunit p36 subunit, DRIP36, ARC36, MED4, VDRIP, TRAP36, HSPC126, FLJ10956, RP11-90M2.2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175221166164,"sku":"PRO-785","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43175221198932,"sku":"PRO-785","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175221231700,"sku":"PRO-785","price":2250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-med4-human-PRO-785.png?v=1776702602"},{"product_id":"med7-human","title":"MED7 Human","description":"\u003cp\u003eMediator Complex Subunit 7 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eMediator complex subunit 7, cofactor required for Sp1 transcriptional activation subunit 9 33kDa, Activator-recruited cofactor 34 kDa component, Transcriptional coactivator CRSP33, RNA polymerase transcriptional regulation mediator subunit 7 homolog, mediator of RNA polymerase II transcription subunit 7, CRSP complex subunit 9, CRSP33, CRSP9, ARC34, hMED7.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175222247508,"sku":"PRO-1319","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175222280276,"sku":"PRO-1319","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175222313044,"sku":"PRO-1319","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-med7-human-PRO-1319.png?v=1776702608"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_6c646e07-d80d-4678-a085-bcb6eb04fc87.png?v=1700647645","url":"https:\/\/prospecbio.com\/collections\/mediator-complex.oembed","provider":"prospecbio","version":"1.0","type":"link"}