{"title":"MAD2","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout MAD2:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eMAD2, standing for mitotic arrest deficient 2, is a spindle checkpoint protein that plays an integral role in the human body. The makeup and biological functionality of this protein is integral to the way the body works, and plays a massive role in the way we live our lives,\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMAD2 Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe mechanism that prevents separation and transition into anaphase is known as spindle checkpoint. This exists primarily as a safeguard against chromosome segregation errors, and delays anaphase until all of the sister chromatid pairs have correctly attached.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMAD2 Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThere are several interactions that MAD2 shares with others, specifically, binding with Cdc20, in a vital protein-to-protein interaction. This happens until all chromosomes are aligned at the metaphase plate. In addition to this interaction, MAD2 also interacts with Chk1, which is integral across multiple points of the cell cycle process, and this is one of the key interactions that plays a massive role in the process.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMAD2 Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe primary function of MAD2 is to accumulate at kinetochores, and generate a wait signal that functions to prevent the cell from progressing to the anaphase of the cell cycle until the appropriate moment, and this is integral to the process.\u003cbr data-mce-fragment=\"1\"\u003eThis is integral to the whole process, and there is much to think about in the future by way of things like spindle checkpoint signaling, as well as the contribution of other proteins that play a role in the process.\u003c\/p\u003e","products":[{"product_id":"mad2l1-human","title":"MAD2L1 Human","description":"\u003cp\u003eMAD2 Mitotic Arrest Deficient-Like 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eMitotic spindle assembly checkpoint protein MAD2A, HsMAD2, Mitotic arrest deficient 2-like protein 1, MAD2-like protein 1, MAD2L1, MAD2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43175081443412,"sku":"PRO-934","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43175081476180,"sku":"PRO-934","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43175081508948,"sku":"PRO-934","price":1100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-mad2l1-human-PRO-934.png?v=1776702002"},{"product_id":"mad2l1bp-human","title":"MAD2L1BP Human","description":"\u003cp\u003eMAD2L1 Binding Protein Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eMAD2L1-binding protein, Caught by MAD2 protein, MAD2L1BP, CMT2, KIAA0110, RP1-261G23.6.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175082950740,"sku":"PRO-1052","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175082983508,"sku":"PRO-1052","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175083016276,"sku":"PRO-1052","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-mad2l1bp-human-PRO-1052.png?v=1776702007"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_712471ae-4953-4584-9ab3-1f0d998bd3d3.png?v=1700647627","url":"https:\/\/prospecbio.com\/collections\/mad2.oembed","provider":"prospecbio","version":"1.0","type":"link"}