{"title":"Lymphotactin (XCL1)","description":"\u003ch3 class=\"highlited\"\u003e\u003cspan\u003eAbout Lymphotactin:\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism\u003c\/strong\u003e\u003cbr\u003eThe family C chemokines — the family to which lymphotactin belongs — differs in structure and function from most other types of chemokines. Chemokines as a whole are known for the role they play in inflammatory and immune responses in the body, but family C chemokines are particularly noteworthy.\u003cbr\u003eThere are only two chemokines that belong to the family C of chemokines. They are both called lymphotactin, and appear in alpha and beta form. The main note of significance in both lymphotactin alpha and beta is that they have only two cysteines: a single N-terminal cysteine and an additional cysteine downstream.\u003cbr\u003eIt has also been noted that both forms of lymphotactin are able to go through reversible conformational changes, which alters its binding shifts.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStructure\u003c\/strong\u003e\u003cbr\u003eAs touched on above, the structure of lymphotactin is what makes it so unique.\u003cbr\u003e● Most chemokines have two disulfide bonds\u003cbr\u003e● However, lymphotactin has only one\u003cbr\u003e● There are two components of the lymphotactin protein — Ltn10 and Ltn40. These components interfold and alter the binding structures, making lymphotactin biologically active.\u003cbr\u003e● This metamorphic folding behavior is quite unique to lymphotactin.\u003cbr\u003e● Lymphotactin is found on chromosome 1, unlike other chemokines which are predominantly found on chromosomes 4 and 17\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunction\u003c\/strong\u003e\u003cbr\u003e● Lymphotactin causes the migration of cells expressing XCR1\u003cbr\u003e● Lymphotactin is found in high levels of numerous organs in the body. These includes the spleen, thymus, lung, prostate gland, and ovaries.\u003cbr\u003e● The data suggests that lymphotactin produced by T cells may have the ability to regulate T cell-mediated immune responses.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInteractions\u003c\/strong\u003e\u003cbr\u003e● Lymphotactin binds with GPCR XCR1 to induce CD8 + T cell and NK cell chemotaxis\u003cbr\u003e● As with other chemokines, lymphotactin has also been found to induce intracellular calcium mobilization and chemotaxis. This is achieved by binding with a specific G protein-coupled receptor\u003cbr\u003e● Furthermore, lymphotactin has been found to chemoattract CD4 + T cells with lower efficiency\u003cbr\u003e● It is produced predominantly through T Cell receptor activation in CD4+ and CD8+ T cells\u003cbr\u003e● It is also produced by NK cells, along with other chemokines, during the earlier stages of an infection\u003cbr\u003e● It is also expressed by dendritic cells\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSignificant notes\u003c\/strong\u003e\u003cbr\u003e● Lymphotactin has been found in T cells that are affected by rheumatoid arthritis, Crohn's Disease, and glomerulonephritis.\u003cbr\u003e● It has therefore been theorized that the suppression of lymphotactin may have a therapeutic value regarding inflammatory and immune disease.\u003cbr\u003e● Lymphotactin has already been used in some cancer immunotherapies, and further research regarding its potential in this area is ongoing.\u003c\/p\u003e","products":[{"product_id":"lymphotactin-human","title":"Lymphotactin Human","description":"\u003cp\u003eLymphotactin Human Recombinant (XCL1)\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eXCL1, Cytokine SCM-1, ATAC, Lymphotaxin, SCM-1-alpha, Small inducible cytokine C1, XC chemokine ligand 1, LTN, LPTN, SCM1, SCM-1, SCYC1, SCM-1a.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"3x2µg","offer_id":43175051395156,"sku":"CHM-314","price":60.0,"currency_code":"USD","in_stock":true},{"title":"2x10µg","offer_id":43175051427924,"sku":"CHM-314","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175051460692,"sku":"CHM-314","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lymphotactin-human-CHM-314.png?v=1776701878"},{"product_id":"lymphotactin-human-his","title":"Lymphotactin Human, His","description":"\u003cp\u003eLymphotactin Human Recombinant (XCL1), His Tag\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eXCL1, Cytokine SCM-1, ATAC, Lymphotaxin, SCM-1-alpha, Small inducible cytokine C1, XC chemokine ligand 1, LTN, LPTN, SCM1, SCM-1, SCYC1, SCM-1a.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175052181588,"sku":"CHM-357","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175052214356,"sku":"CHM-357","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175052247124,"sku":"CHM-357","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lymphotactin-human-his-CHM-357.png?v=1776701883"},{"product_id":"lymphotactin-mouse","title":"Lymphotactin Mouse","description":"\u003cp\u003eLymphotactin (XCL1) Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eXCL1, Cytokine SCM-1, ATAC, Lymphotaxin, SCM-1-alpha, Small inducible cytokine C1, XC chemokine ligand 1, LTN, LPTN, SCM1, SCM-1, SCYC1, SCM-1a.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"50µg","offer_id":43175053066324,"sku":"CHM-037","price":400.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43175053099092,"sku":"CHM-037","price":600.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175053131860,"sku":"CHM-037","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lymphotactin-mouse-CHM-037.png?v=1776701887"},{"product_id":"lymphotactin-rat","title":"Lymphotactin Rat","description":"\u003cp\u003eLymphotactin (XCL1) Rat Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eXCL1, Cytokine SCM-1, ATAC, Lymphotaxin, SCM-1-alpha, Small inducible cytokine C1, XC chemokine ligand 1, LTN, LPTN, SCM1, SCM-1, SCYC1, SCM-1a.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"50µg","offer_id":43175053951060,"sku":"CHM-038","price":400.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43175053983828,"sku":"CHM-038","price":600.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175054016596,"sku":"CHM-038","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lymphotactin-rat-CHM-038.png?v=1776701891"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_06349772-d4f0-4df0-b633-ff7eb431911f.png?v=1700647622","url":"https:\/\/prospecbio.com\/collections\/lymphotactin-xcl1.oembed","provider":"prospecbio","version":"1.0","type":"link"}