{"title":"Lipase","description":"\u003ch3 class=\"highlited\"\u003e\u003cspan\u003eAbout Lipase:\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003eOtherwise known as triacylglycerol acylhydrolases, Lipase enzymes are defined as any enzyme that serves as a catalyst in the hydrolysis of lipids fats, and are found as a subclass of the esterases.\u003cbr\u003eBuilt on an alpha\/beta hydrolase fold, they use a chymotrypsin-like hydrolysis mechanism courtesy of a catalytic triad of a histidine base, serine nucleophile, and acid residue.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLipase Function\u003c\/strong\u003e\u003cbr\u003eLipase enzymes are found in an array of living organisms. As far as human biology is concerned, they are primarily associated with the digestive system. Both the pancreatic lipase (PL) and pancreatic lipase related protein 2 (PLRP2) are secreted by the pancreas while the hepatic lipase, endothelial lipase, and lipoprotein lipase also function within the gut.\u003cbr\u003eNot all lipases are found in the gut, though. For example, the lingual lipase is secreted by the Ebner's glands located at the back of the tongue as well as other salivary glands including the sublingual glands and the parotid glands. Their impact on digestion is crucial while blood tests focused on the lipase levels can help identify conditions such as acute pancreatitis.\u003cbr\u003eLipase enzymes can be found in the blood, gastric juices, pancreatic secretions, intestinal juices, and adipose tissues functioning to hydrolyse triglycerides (fats) into their component fatty acid and glycerol molecules.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLipase Mechanism\u003c\/strong\u003e\u003cbr\u003eLipase digestion begins when bile salts lower the surface tension of the fat droplets within the lumen of the small intestine, allowing lipases to attack triglyceride molecules. Fatty acids and glycerol molecules are then transported through the epithelial cells of the intestine wall before being resynthesizsed into triglycerides. They are then transported to muscles and tissues to hydrolyse the triglycerides.\u003cbr\u003eLipases break down the triglycerides, enabling fatty acids to reenter the bloodstream, promoting the transport to the tissues that need the energy from those fats. Lipases can, therefore, be used by the body in a diverse range of biological processes such as dietary triglycerides, cell signaling, and inflammation. They can be secreted to extracellular spaces, breaking down the molecules into solutions that can be easily absorbed and transported throughout the body.\u003cbr\u003eDifferent lipase enzymes serve different functions. For example, the gastric lipase targets butterfat by stimulating the bile that is activated by the gallbladder when we eat fats.\u003c\/p\u003e","products":[{"product_id":"mgll-human","title":"MGLL Human","description":"\u003cp\u003eMonoglyceride Lipase Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eMonoglyceride lipase, MGL, HU-K5, Lysophospholipase homolog, Lysophospholipase-like, Monoacylglycerol lipase, MAGL, MGLL, 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