{"title":"lif - Leukemia Inhibitory Factor","description":"\u003ch3 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout Leukemia Inhibitory Factor [ LIF ]:\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eLeukemia Inhibitory Factor [ LIF ] is a protein that induces the terminal differentiation of myeloid leukemic cells, thus preventing the continued growth of these cells.\u003cbr data-mce-fragment=\"1\"\u003eEssentially, myeloid leukemia is a form of blood cancer that can be life-threatening. Leukemia Inhibitory Factor, a naturally-occurring protein, is something we all have, and can help to force leukemic cells to differentiate rather than multiplying. Leukemia Inhibitory Factor is likely to be a key aspect that stops us all from developing myeloid leukemia. However, in certain cases -- and often fuelled by other genetic factors -- the supply of Leukemia Inhibitory Factor runs short, and cannot encourage all dangerous cells to differentiate. It is at this point that leukemia is diagnosed, and the threat to life develops.\u003cbr data-mce-fragment=\"1\"\u003eAdditionally, Leukemia Inhibitory Factor promotes growth and cell differentiation in a range of different target cells.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eFunction\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThere are multiple functions of Leukemia Inhibitory Factor -- from hereon referred to as LIF for the sake of brevity -- which are noted as follows…\u003cbr data-mce-fragment=\"1\"\u003e● LIF restricts the growth of myeloid leukemia cells. Even if cells are cancerous, they cannot grow when there is sufficient LIF;\u003cbr data-mce-fragment=\"1\"\u003e● LIF also assists with the metabolism of healthy bone marrow and matter;\u003cbr data-mce-fragment=\"1\"\u003e● LIF supports neural development;\u003cbr data-mce-fragment=\"1\"\u003e● Furthermore, muscle regeneration is improved when LIF quantities are sufficient;\u003cbr data-mce-fragment=\"1\"\u003e● Embryogenesis also requires LIF\u003cbr data-mce-fragment=\"1\"\u003e● LIF is used as a treatment for a wasting condition known as Cachexia. Cachexia is seen in patients with AIDS, cancer, and other serious illnesses; the presence of Cachexia is considered a severe risk factor for terminal prognosis.\u003cbr data-mce-fragment=\"1\"\u003e● In patients with multiple sclerosis, LIF can help to tip the immune balance towards regulatory T-cells, improving prognosis and providing better condition management.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eInteractions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003e● LIF binds to a specific receptor (LIFR-α), which leads to the activation of the JAK\/STAT and MAPK cascades.\u003cbr data-mce-fragment=\"1\"\u003e● LIF is often added to stem cell culture media, as an alternative to feeder cell culture. This avoids this limitation that feeder cells can present, caused by the fact that feeder cells only produce LIF on their surface. When LIF is directly added to the culture media, satisfactory results from treatment are more likely.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eThoughts For The Future\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eAt present, LIF is understood, and used to good effect, but there is undoubtedly room for further investigation. LIF is primarily used in the treatment of myeloid leukemia; it remains to be see whether it can offer any hope in other blood cancers. Promising results have been shown in trials for its application on cutaneous melanoma.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eAvailability\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eProSpec carries a range of LIF proteins, including human, mouse, and rat species. Adequate\/relevant temperature control is guaranteed during the shipment process, so you can be confident of safe arrival; LIF can be purchased in quantities from 2µg, 10ug, 100ug, 500ug through to 1mg for use in research and development. We are confident you will be highly satisfied with our LIF offerings.\u003c\/p\u003e","products":[{"product_id":"lif-human","title":"LIF Human","description":"\u003cp\u003eLeukemia Inhibitory Factor Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCDF, HILDA, D-FACTOR, Differentiation- stimulating factor, Melanoma-derived LPL inhibitor, MLPLI, Emfilermin, Leukemia inhibitory factor, LIF, DIA.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174967017556,"sku":"CYT-644","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43174967050324,"sku":"CYT-644","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174967083092,"sku":"CYT-644","price":2520.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lif-human-CYT-644.png?v=1776701500"},{"product_id":"lif-human-gst","title":"LIF Human, GST","description":"\u003cp\u003eLeukemia Inhibitory Factor, GST tag Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eD factor, MLPLI, HILDA, Emfilermin, Leukemia Inhibitory factor, Differentiation-stimulating factor, Melanoma-derived LPL inhibitor.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174967967828,"sku":"CYT-001","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174968000596,"sku":"CYT-001","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174968033364,"sku":"CYT-001","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lif-human-gst-CYT-001.png?v=1776701504"},{"product_id":"lif-protein","title":"LIF Human, His","description":"\u003cp\u003eLeukemia Inhibitory Factor Human Recombinant, His tag\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCDF, HILDA, D-FACTOR, Differentiation- stimulating factor, Melanoma-derived LPL inhibitor, MLPLI, Emfilermin, Leukemia inhibitory factor, LIF, DIA.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174969704532,"sku":"CYT-1082","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174969737300,"sku":"CYT-1082","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174969770068,"sku":"CYT-1082","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lif-protein-CYT-1082.png?v=1776701529"},{"product_id":"lif-human-sf9","title":"LIF Human, Sf9","description":"\u003cp\u003eLeukemia Inhibitory Factor Human Recombinant, Sf9\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eLeukemia Inhibitory Factor, Differentiation Inhibitory Activity, Cholinergic Differentiation Factor, Differentiation-Stimulating Factor, Hepatocyte-Stimulating Factor III, Differentiation-Inducing Factor, Melanoma-Derived LPL Inhibitor, Human Interleukin In DA Cells, D Factor, HILDA, MLPLI, Emfilermin, DIA, CDF, Leukemia inhibitory factor, LIF, Differentiation-stimulating factor, D factor, Melanoma-derived LPL inhibitor, MLPLI, Emfilermin.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174970687572,"sku":"CYT-1003","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174970720340,"sku":"CYT-1003","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174970753108,"sku":"CYT-1003","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lif-human-sf9-CYT-1003.png?v=1776701514"},{"product_id":"lif-human-yeast","title":"LIF Human, Yeast","description":"\u003cp\u003eLIF Human Recombinant, Yeast\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCDF, HILDA, D-FACTOR, Differentiation- stimulating factor, Melanoma-derived LPL inhibitor, MLPLI, Emfilermin, Leukemia inhibitory factor, LIF, DIA.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174971736148,"sku":"CYT-191","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43174971768916,"sku":"CYT-191","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174971801684,"sku":"CYT-191","price":3600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lif-human-yeast-CYT-191.png?v=1776701520"},{"product_id":"lif-mouse","title":"LIF Mouse","description":"\u003cp\u003eLeukemia Inhibitory Factor Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCDF, HILDA, D-FACTOR, Differentiation- stimulating factor, Melanoma-derived LPL inhibitor, MLPLI, Emfilermin, Leukemia inhibitory factor, LIF, DIA.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174972686420,"sku":"CYT-645","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43174972719188,"sku":"CYT-645","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174972751956,"sku":"CYT-645","price":2520.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lif-mouse-CYT-645.png?v=1776701525"},{"product_id":"lif-rat","title":"LIF Rat","description":"\u003cp\u003eLeukemia Inhibitory Factor Rat Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eLeukemia inhibitory factor, Cholinergic neuronal differentiation factor, Lif.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174973341780,"sku":"CYT-731","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174973374548,"sku":"CYT-731","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174973407316,"sku":"CYT-731","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lif-rat-CYT-731.png?v=1776701535"},{"product_id":"lifr-human","title":"LIFR Human","description":"\u003cp\u003eLeukemia Inhibitory Factor Receptor Alpha Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eLeukemia Inhibitory Factor Receptor Alpha, CD118 Antigen,\nLIF Receptor, LIF-R, Leukemia Inhibitory Factor Receptor, CD118, SJS2, STWS, SWS,\nLeukemia inhibitory factor receptor, LIF receptor, LIF-R.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174974095444,"sku":"CYT-949","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174974128212,"sku":"CYT-949","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174974160980,"sku":"CYT-949","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lifr-human-CYT-949.png?v=1776701540"},{"product_id":"lifr-mouse","title":"LIFR Mouse","description":"\u003cp\u003eLeukemia Inhibitory Factor Receptor Alpha Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eLeukemia inhibitory factor receptor, LIF receptor, LIF-R, D-factor\/LIF receptor, CD118, CD antigen, leukemia inhibitory factor receptor isoform 1 precursor, Lifr.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174974849108,"sku":"CYT-1170","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174974881876,"sku":"CYT-1170","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174974914644,"sku":"CYT-1170","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lifr-mouse-CYT-1170.png?v=1776701545"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_fd632907-02e1-4b20-b4dd-2ae93d781abc.png?v=1700647611","url":"https:\/\/prospecbio.com\/collections\/lif-leukemia-inhibitory-factor.oembed","provider":"prospecbio","version":"1.0","type":"link"}