{"title":"Leukocyte-Associated Ig-Like Receptor","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout LAIR \/ Leukocyte-Associated Ig-Like Receptor:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eLeukocyte associated immunoglobulin, or more commonly known as LAIR-1 is an immune inhibitory receptor. It is a glycoprotein of 287 amino acids containing a single extracellular C2-type. The genes encoding LAIR-1 are found on the leukocyte receptor on human chromosome 19.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eLAIR Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eFound within immune cells, it has a plethora of ligands found in circulation and tissue. It is an ITIM-bearing collagen receptor expressed by leukocytes hence why it is found on skin immune cells - most often on CD14+ cells. This receptor contains two vital immunoreceptor tyrosine-based motifs. These are better known as ITIMs. It is found within almost all immune cells and commonly found within T cells, B cells as well as monocytes and mast cells and more.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eLeukocyte-Associated Ig-Like Receptor Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eWhen activated they are found within neutrophils. It is known that LAIR is activated during the inflammatory phase of an immune response; such as following a vaccine. With inflammatory conditions, such as sinusitis or asthma, LAIR-1 has an inhibitory function. This means that it inhibits immune cell activation in certain scenarios. LAIR-1 has been studied for many years and it was found in a test on mice, to exacerbate and accelerate an in vivo tumor when overexpressed. It may also be attributed to RCC progression, which is also known as renal cell carcinoma. In autoimmune diseases such as Rheumatoid Arthritis, there are studies that look at ways to suppress T-cell activation by using LAIR-1. It is known that LAIR-1 activation could be used in the control of certain inflammatory and autoimmune diseases. When it meets collagen or C1q, it inhibits TCR signaling.\u003c\/p\u003e","products":[{"product_id":"lair1-human","title":"LAIR1 Human","description":"\u003cp\u003eLeukocyte-Associated Ig-Like Receptor 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eLeukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, CD305 antigen, LAIR1, CD305.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174850232404,"sku":"PRO-431","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174850265172,"sku":"PRO-431","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174850297940,"sku":"PRO-431","price":2800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lair1-human-PRO-431.png?v=1776700942"},{"product_id":"lair1-mouse","title":"LAIR1 Mouse","description":"\u003cp\u003eLeukocyte-Associated Ig-Like Receptor 1 Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eLeukocyte-associated immunoglobulin-like receptor 1, LAIR-1, mLAIR1, CD305, LAIR1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174851215444,"sku":"PRO-2356","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174851248212,"sku":"PRO-2356","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174851280980,"sku":"PRO-2356","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lair1-mouse-PRO-2356.png?v=1776700947"},{"product_id":"lair2-human","title":"LAIR2 Human","description":"\u003cp\u003eLeukocyte-Associated Ig-Like Receptor 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eLeukocyte-associated immunoglobulin-like receptor 2, LAIR-2, CD306, LAIR2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174852132948,"sku":"PRO-1081","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174852165716,"sku":"PRO-1081","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174852198484,"sku":"PRO-1081","price":3600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lair2-human-PRO-1081.png?v=1776700951"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_f37194b2-fa49-4d4b-8b7a-c6ca7f6d4716.png?v=1700647595","url":"https:\/\/prospecbio.com\/collections\/leukocyte-associated-ig-like-receptor.oembed","provider":"prospecbio","version":"1.0","type":"link"}