{"title":"Kruppel-Like Factor","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout KLF \/ Kruppel-Like Factor:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eKLF also known as Krupel Like Factors are zinc finger proteins, and they are part of the DNA-binding domain. When they bind with CACCC or GT, they respond as either activators or repressors and regulate gene expression.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eKLF Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThey have two main components, which are a co-activator and a transactivator. Discovered in 1996, they help to regulate cellular processes which include cell growth, proliferation, and differentiation. Krüppel-like Factors are part of the Sp transcription factor and their related proteins. They range from KLF1 to KLF17. Sp1-4 and Sp5-9 are the groups that they are divided into.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eKruppel-Like Factor Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe KLF are found frequently throughout the downstream genes, and play a major role in the development of the nervous system. They also play a role in the heart and gut.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eKLF Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThese KLFs contain three carboxyl-terminal motifs. These motifs bind to DNA which help to regulate the cells. They also provide regulation of functions that include proliferation and differentiation to name a couple. As mentioned, there are three subgroups of KLFs. These include the KLF 3, 8 and 12. There are transcription activators KLFs 9,10, 11, 12, 12, 12 and 16. There have been numerous studies relating to the structure and function of KLFs. Artificial factors can be used to activate or repress genes. Cancer changes the function of KLFs and regulates cancerous cells. Understanding their functions could lead to a new treatment discovery.\u003c\/p\u003e","products":[{"product_id":"klf12-human","title":"KLF12  Human","description":"\u003cp\u003eKruppel-Like Factor 12 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eAP-2rep, AP2REP, HSPC122, Krueppel-like factor 12, Transcriptional\nrepressor AP-2rep.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174773325908,"sku":"PRO-2090","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174773358676,"sku":"PRO-2090","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174773391444,"sku":"PRO-2090","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-klf12-human-PRO-2090.png?v=1776700540"},{"product_id":"klf3-human","title":"KLF3 Human","description":"\u003cp\u003eKruppel-Like Factor 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eATP Synthase H+ Transporting, Mitochondrial Fo Complex Subunit D, ATP Synthase D Chain Mitochondrial, ATP Synthase H+ Transporting Mitochondrial F1F0 Subunit D, ATPase Subunit D, My032 Protein, ATPQ. Kruppel-Like Factor 3 (Basic), CACCC-Box-Binding Protein BKLF , Basic Kruppel Like Factor, Krueppel-Like Factor 3, Transcript Ch138, BKLF, TEF-2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174774079572,"sku":"PRO-1632","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174774112340,"sku":"PRO-1632","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174774145108,"sku":"PRO-1632","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-klf3-human-PRO-1632.png?v=1776700544"},{"product_id":"klf4-human","title":"KLF4 Human","description":"\u003cp\u003eKruppel-Like Factor 4 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eKruppel-like factor 4 (gut), EZF, GKLF, Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor, endothelial Kruppel-like zinc finger protein.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174776176724,"sku":"PRO-891","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174776209492,"sku":"PRO-891","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174776242260,"sku":"PRO-891","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-klf4-human-PRO-891.png?v=1776700559"},{"product_id":"klf4-human-his","title":"KLF4 Human, His","description":"\u003cp\u003eKruppel-Like Factor 4 Human Recombinant, His Tag\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eKruppel-Like\nFactor 4 (Gut), GKLF, EZF, Epithelial Zinc Finger Protein EZF, Gut-Enriched\nKrueppel-Like Factor, Endothelial Kruppel-Like Zinc Finger Protein,\nKrueppel-Like Factor 4, Krueppel-like factor 4, Epithelial zinc finger protein\nEZF, Gut-enriched krueppel-like factor.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174776930388,"sku":"PRO-2186","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174776963156,"sku":"PRO-2186","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174776995924,"sku":"PRO-2186","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-klf4-human-his-PRO-2186.png?v=1776700554"},{"product_id":"klf6-human","title":"KLF6 Human","description":"\u003cp\u003eKruppel-Like Factor 6 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eKrueppel-like factor 6, B-cell-derived protein 1, Core promoter element-binding protein, GC-rich sites-binding factor GBF, Proto-oncogene BCD1, Suppressor of tumorigenicity 12 protein, Transcription factor Zf9, KLF6, BCD1, COPEB, CPBP, ST12.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174778110036,"sku":"PRO-1864","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174778142804,"sku":"PRO-1864","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174778175572,"sku":"PRO-1864","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-klf6-human-PRO-1864.png?v=1776700564"},{"product_id":"klf7-protein","title":"KLF7 (80-230) Human","description":"\u003cp\u003eKruppel-Like Factor 7 (80-230) Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eUKLF, Krueppel-like factor 7, Ubiquitous krueppel-like factor, KLF7.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"50µg","offer_id":43174778798164,"sku":"PRO-2824","price":200.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174778830932,"sku":"PRO-2824","price":300.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174778863700,"sku":"PRO-2824","price":1500.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-klf7-protein-PRO-2824.png?v=1776700578"},{"product_id":"klf7-human","title":"KLF7 Human","description":"\u003cp\u003eKruppel-Like Factor 7 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eUKLF, Krueppel-like factor 7, Ubiquitous krueppel-like factor, KLF7.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174780502100,"sku":"PRO-1527","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174780534868,"sku":"PRO-1527","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174780567636,"sku":"PRO-1527","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-klf7-human-PRO-1527.png?v=1776700573"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_35d2eba0-0187-40a1-8c01-5b97e89a28cd.png?v=1700647583","url":"https:\/\/prospecbio.com\/collections\/kruppel-like-factor.oembed","provider":"prospecbio","version":"1.0","type":"link"}