{"title":"IP-10 (CXCL10)","description":"\u003ch3 class=\"highlited\"\u003e\u003cspan\u003eAbout IP-10 \/ CXCL10:\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism\u003c\/strong\u003e\u003cbr\u003e● CXCL10 is an abbreviation for the full name of the protein, which is: C-X-C motif chemokine 10.\u003cbr\u003e● CXCL10, like most proteins, has other names. It is also known as Interferon-gamma-induced protein 10, or IP-10 for short.\u003cbr\u003e● It is also known as small-inducible cytokine B10.\u003cbr\u003e● CXCL10 is encoded in the human gene of the same name.\u003cbr\u003e● CXCL10 is a cytokine that is a member of the CXC chemokine family.\u003cbr\u003e● CXCL10 is located in human chromosome 4, along with numerous other CXC chemokines.\u003c\/p\u003e\n\u003cp\u003eCXCL10 has been found to have a number of roles in the human body, including:\u003cbr\u003e❖ Chemoattraction for monocytes\/macrophages, T cells, dendritic cells, and NK cells.\u003cbr\u003e❖ CXCL10 is also involved in the promotion of T cell adhesion to endothelial cells\u003cbr\u003e❖ Also known for roles in antitumor activity, bone marrow colony formation, and angiogenesis\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStructure\u003c\/strong\u003e\u003cbr\u003e● CXCL10 has a three-dimensional crystal structure.\u003cbr\u003e● It has been determined under three different conditions to a resolution of up to 1.92 Å\u003cbr\u003e● With the Protein Data bank, the accession codes regarding the structures of CXCL10 are as followed: 1lv9, 1o7y, and 1o80.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunction\u003c\/strong\u003e\u003cbr\u003e● As a member of the alpha chemokine family, CXCL10 is known to inhibit bone marrow colony formation.\u003cbr\u003e● It has also been linked with antitumor activity in vivo.\u003cbr\u003e● CXCL10 is also a chemoattractant for T cells and human monocytes.\u003cbr\u003e● CXCL10 is also known to promote T cell adhesion to endothelial cells\u003cbr\u003e● Furthermore, CXCL10 is known to be a potent inhibitor of angiogenesis in vivo.\u003cbr\u003e● The results of studies have concluded that CXCL10 may have a role in the regulation of angiogenesis during both inflammation and tumorigenesis.\u003cbr\u003e● CXCL10 produces its effects by binding to the cell surface chemokine receptor CXCR3.\u003c\/p\u003e\n\u003cp\u003eIn addition to the above, CXCL10 has been proven to be secreted by several cell types in response to IFN-γ. The cell types that secrete CXCL10 include:\u003cbr\u003e❖ Monocytes\u003cbr\u003e❖ Endothelial cells\u003cbr\u003e❖ Fibroblasts\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSignificant notes\u003c\/strong\u003e\u003cbr\u003e● Along with CXCL9 and CXCL11, CXCL10 is a proven biomarker for the development of heart failure and left ventricular dysfunction.\u003cbr\u003e● This suggests that this group of chemokines may have a pathophysiological relation to adverse cardiac modeling.\u003cbr\u003e● Furthermore, in hepatitis C patients, CXCL10 is elevated in baseline pre-treatment plasma levels.\u003cbr\u003e● It is suspected that when pre-treatment levels of CXCL10 are below 150 pg\/mL, a more favorable response to treatment is likely for those suffering from hepatitis C.\u003cbr\u003e● Additionally, studies have suggested that anti-CXCL10 treatment may successfully be able to impede the development of inflammatory bowel disease.\u003cbr\u003e● Finally, animal models have also suggested that CXCL10, and its receptor, CXCR3, may have a role to play in the treatment of behavioral changes during type I interferon therapy and virus infections.\u003c\/p\u003e","products":[{"product_id":"ip-10-human","title":"IP 10 Human","description":"\u003cp\u003eIP-10 Human Recombinant (CXCL10)\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSmall inducible cytokine B10, CXCL10, 10 kDa, Gamma-IP10, IP-10, chemokine (C-X-C motif) ligand 10, C7, IFI10, INP10, crg-2, mob-1, SCYB10, 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