{"title":"Integrin","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout ITGB \/ Integrin:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003entegrin or ITGB as it is more commonly referred to has been discovered to be a transmembrane receptor. It is vital in cell to cell and cell to extracellular matrix adhesion (ECM).\u003cbr data-mce-fragment=\"1\"\u003eRegulation of the cell cycle, intracellular cytoskeleton organization, and new receptor movement are all possible due to the ligand-binding activating the active signal transduction pathways.\u003cbr data-mce-fragment=\"1\"\u003eITGB’s presence in the body allows rapid response to cell surface events. There are a number of integrin types and they are found in all humans and animal species.\u003cbr data-mce-fragment=\"1\"\u003eThere are a number of clinical studies currently taking place which are investigating the pharmacological targeting of ITGB to treat tissue fibrosis in the lungs, kidney, and liver. The medical and pharmacological role of integrins is an important step in the quest to find new treatments for certain life-limiting and untreatable conditions.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eITGB Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eITGB consists of 18 a and 8 b subunits. These subunits can assemble to form 24 completely different receptors, each with a unique binding property. Each subunit has a helix spanning a single membrane and a relatively short cytoplasmic tail. The a subunits contain 1000 amino acids and the b subunits contain 750 amino acids.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eIntegrin Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eITGBs are known to be traction receptors that can detect and transmit changes in the force that is acting on the ECM. In most mammals, ITGB is only found in particular cell types or tissue.\u003cbr data-mce-fragment=\"1\"\u003eIn fibronectin, the RGD sequence has been identified as an integrin-binding motif yet they also recognize non-RGD sequences in the ITGB ligands.\u003c\/p\u003e","products":[{"product_id":"itgb1-human","title":"ITGB1 Human","description":"\u003cp\u003eIntegrin Beta 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eIntegrin beta-1, Fibronectin receptor subunit beta, Glycoprotein IIa, GPIIA, VLA-4 subunit beta, CD29, ITGB1, FNRB, MDF2, MSK12, Integrin beta 1, CD29, VLAB.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174712377428,"sku":"PRO-1817","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174712410196,"sku":"PRO-1817","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174712442964,"sku":"PRO-1817","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-itgb1-human-PRO-1817.png?v=1776700209"},{"product_id":"itgb1-human-sf9","title":"ITGB1 Human, Sf9","description":"\u003cp\u003eIntegrin Beta 1 Human Recombinant, Sf9\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eIntegrin beta-1, Fibronectin receptor subunit beta, Glycoprotein IIa, GPIIA, VLA-4 subunit beta, CD29, ITGB1, FNRB, MDF2, MSK12, Integrin beta 1, CD29, VLAB.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174713491540,"sku":"PRO-2410","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174713524308,"sku":"PRO-2410","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174713557076,"sku":"PRO-2410","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-itgb1-human-sf9-PRO-2410.png?v=1776700213"},{"product_id":"itgb1bp3-human","title":"ITGB1BP3 Human","description":"\u003cp\u003eIntegrin Beta 1 Binding Protein 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eNicotinamide riboside kinase 2, Ribosylnicotinamide kinase 2, Ribosylnicotinic acid kinase 2, ITGB1BP3, MIBP, NRK2, NmR-K 2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174714343508,"sku":"PRO-1177","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174714376276,"sku":"PRO-1177","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174714409044,"sku":"PRO-1177","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-itgb1bp3-human-PRO-1177.png?v=1776700218"},{"product_id":"itgb3bp-human","title":"ITGB3BP Human","description":"\u003cp\u003eIntegrin Beta 3 Binding Protein Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCENP-R, CENPR, HSU37139, NRIF3, TAP20, Centromere protein R, Beta-3-endonexin, Integrin beta-3-binding protein, Nuclear receptor-interacting factor 3, ITGB3BP.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174715326548,"sku":"PRO-1435","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174715359316,"sku":"PRO-1435","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174715392084,"sku":"PRO-1435","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-itgb3bp-human-PRO-1435.png?v=1776700222"},{"product_id":"itgb4-human","title":"ITGB4 Human","description":"\u003cp\u003eIntegrin Beta 4 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eIntegrin beta-4, GP150, CD104, ITGB4, Integrin Subunit Beta 4, CD104 Antigen, Integrin, Beta 4, Integrin Beta-4.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174716407892,"sku":"PRO-2528","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174716440660,"sku":"PRO-2528","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174716473428,"sku":"PRO-2528","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-itgb4-human-PRO-2528.png?v=1776700226"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_f8468a0d-012b-4481-9680-8efdff8434fd.png?v=1700647572","url":"https:\/\/prospecbio.com\/collections\/integrin.oembed","provider":"prospecbio","version":"1.0","type":"link"}