{"title":"IMPAD1","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout IMPAD1 \/ Inositol Monophosphatase Domain Containing 1:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eInositol monophosphatase 3, also known as inositol monophosphatase domain-containing protein 1 (IMPAD1), is an enzyme that is encoded by the IMPAD1 gene in humans. The gene is a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP).\u003cbr data-mce-fragment=\"1\"\u003eIMPAD1 also functions as a mitochondrial electron transport inhibitor that prevents ROS production and also promotes the metastasis of lung cancer through the AMPK-Notch1-HEY1 pathway. Studies have identified IMPAD1 from the conditioned medium of highly-invasive CL1-5.\u003cbr data-mce-fragment=\"1\"\u003eIMPAD1 may also play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation.\u003cbr data-mce-fragment=\"1\"\u003eOther aliases of IMPAD1 include BPNT2, GPAPP, IMP 3, IMP-3, IMPA3, inositol monophosphatase domain containing 1, IMPAD1, 3'(2'), and 5'-bisphosphate nucleotidase 2.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eIMPAD1 Protein type\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eCell development\/differentiation; EC 3.1.3.25; EC 3.1.3.7; Membrane protein, integral; Phosphatase (non-protein)\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eInositol Monophosphatase Domain Containing 1Cellular Components\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eCytosol, Golgi apparatus, Golgi lumen, integral component of membrane, nuclear body, nucleus.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eIMPAD1 Functions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe main molecular functions of IMPAD1 include 3'(2'),5'-bisphosphate nucleotidase activity, inositol monophosphate 1-phosphatase activity, inositol monophosphate 3-phosphatase activity, inositol monophosphate 4-phosphatase activity, and metal ion binding.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eInositol Monophosphatase Domain Containing 1 Cellular Clinical significance\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eMutations in the IMPAD1 gene are a cause of GRAPP-type chondrodysplasia with joint dislocations. A pseudogene of this gene is located on the long arm of chromosome 1.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eIMPAD1 Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eCurrently, there is no solved structure for IMPAD1.\u003c\/p\u003e","products":[{"product_id":"impad1-human","title":"IMPAD1 Human","description":"\u003cp\u003eInositol Monophosphatase Domain Containing 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eInositol monophosphatase 3, IMP 3, IMPase 3, EC 3.1.3.25, EC 3.1.3.7, Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase, Golgi-resident PAP phosphatase, gPAPP, Inositol monophosphatase domain-containing protein 1, Inositol-1(or 4)-monophosphatase 3, Myo-inositol monophosphatase A3, IMPAD1, IMPA3, GPAPP, IMP-3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174651265108,"sku":"PRO-1346","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174651297876,"sku":"PRO-1346","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174651330644,"sku":"PRO-1346","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-impad1-human-PRO-1346.png?v=1776699792"},{"product_id":"impad1-protein","title":"IMPAD1 Human, Active","description":"\u003cp\u003eInositol Monophosphatase Domain Containing 1 Human Recombinant, BioActive\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eInositol monophosphatase 3, IMP 3, IMPase 3, EC 3.1.3.25, EC 3.1.3.7, Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase, Golgi-resident PAP phosphatase, gPAPP, Inositol monophosphatase domain-containing protein 1, Inositol-1(or 4)-monophosphatase 3, Myo-inositol monophosphatase A3, IMPAD1, IMPA3, GPAPP, IMP-3\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174651986004,"sku":"PRO-2638","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174652018772,"sku":"PRO-2638","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174652051540,"sku":"PRO-2638","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-impad1-protein-PRO-2638.png?v=1776699806"},{"product_id":"impad1-mouse","title":"IMPAD1 Mouse","description":"\u003cp\u003eInositol Monophosphatase Domain Containing 1 Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eInositol monophosphatase\n  3, IMP 3, IMPase 3, Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime\n  phosphatase, Golgi-resident PAP phosphatase, gPAPP, Inositol monophosphatase\n  domain-containing protein 1, Inositol-1(or 4)-monophosphatase 3 Myo-inositol\nmonophosphatase A3, Impad1, Impa3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174652903508,"sku":"PRO-2314","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174652936276,"sku":"PRO-2314","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174652969044,"sku":"PRO-2314","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-impad1-mouse-PRO-2314.png?v=1776699802"},{"product_id":"impad1-mouse-bioactive","title":"IMPAD1 Mouse Bioactive","description":"\u003cp\u003eInositol Monophosphatase Domain Containing 1 Mouse Recombinant Bioactive\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eInositol monophosphatase 3, IMP 3, IMPase 3, Golgi 3-prime\nphosphoadenosine 5-prime phosphate 3-prime phosphatase, Golgi-resident PAP\nphosphatase, gPAPP, Inositol monophosphatase domain-containing protein 1, Inositol-1(or\n4)-monophosphatase 3, Myo-inositol monophosphatase A3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174653591636,"sku":"PRO-2380","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174653624404,"sku":"PRO-2380","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174653657172,"sku":"PRO-2380","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-impad1-mouse-bioactive-PRO-2380.png?v=1776699797"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_216d604c-84bd-48b5-8bcc-4df357c979c2.png?v=1700647562","url":"https:\/\/prospecbio.com\/collections\/impad1.oembed","provider":"prospecbio","version":"1.0","type":"link"}