{"title":"Ig Heavy Chain Constant Region","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout Ig Heavy Chain Constant Region:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe immunoglobulin heavy chain (IgH) is the large polypeptide subunit of an antibody (immunoglobulin). In the human genome, the IgH gene loci are on chromosome 14.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eIg Heavy Chain Constant Region Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eTypical antibodies are composed of two immunoglobulin (Ig) heavy chains and two Ig light chains. There are several different types of heavy chain that define the class or isotype of an antibody. These heavy chain types can differ between animals.\u003cbr data-mce-fragment=\"1\"\u003eAll heavy chains contain a series of immunoglobulin domains. They typically have one variable domain (VH) that is essential for binding antigen and several constant domains such as CH1, CH2, and so forth. Production of a viable heavy chain is a crucial step in B cell maturation. If the heavy chain can bind to a surrogate light chain and move to the plasma membrane, the developing B cell can produce its own light chain.\u003cbr data-mce-fragment=\"1\"\u003eHowever, the heavy chain doesn’t necessarily need to bind to a light chain. Pre-B lymphocytes can synthesize heavy chain without the need for light chain. This allows the heavy chain to bind to a heavy-chain binding protein\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eIg Heavy Chain Constant Region Classes\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThere are five different types of mammalian immunoglobulin heavy chain: γ, δ, α, μ and ε. They define classes of immunoglobulins: IgG, IgD, IgA, IgM and IgE, respectively. Heavy chains α and γ have approximately 450 amino acids, while μ and ε have approximately 550 amino acids.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eIg Heavy Chain Constant Region Regions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eHeavy chains have two regions; a constant region and a variable region.\u003cbr data-mce-fragment=\"1\"\u003eThe constant region for heavy chains γ, α and δ have a constant region composed of three tandem immunoglobulin domains. There is also a hinge for flexibility. For heavy chains μ and ε, the constant region is composed of four domains.\u003cbr data-mce-fragment=\"1\"\u003eVariable regions differ between B cells, but is the same for immunoglobulins produced by the same B cell or B cell clone.\u003c\/p\u003e","products":[{"product_id":"igg-mouse","title":"IgG Mouse","description":"\u003cp\u003eImmunoglobulin Heavy Chain Constant Region Gamma 2a Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eIg gamma-2A chain C region, A allele, Immunoglobulin heavy chain gamma polypeptide, Ighg, Igh-1, Igh-1a, 1810060O09Rik.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174354255956,"sku":"PRO-1087","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174354288724,"sku":"PRO-1087","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174354321492,"sku":"PRO-1087","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-igg-mouse-PRO-1087.png?v=1776698252"},{"product_id":"igg-mouse-his","title":"IgG Mouse, His","description":"\u003cp\u003eImmunoglobulin Heavy Chain Constant Region Gamma 2a Mouse Recombinant, His Tag\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eIg gamma-2A chain C region, A allele, Immunoglobulin heavy chain gamma polypeptide, Ighg, Igh-1, Igh-1a, 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IGG1-FC\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174355927124,"sku":"PRO-2763","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174355959892,"sku":"PRO-2763","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174355992660,"sku":"PRO-2763","price":3200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-igg1-fc-human-PRO-2763.png?v=1776698256"},{"product_id":"igj-human","title":"IGJ Human","description":"\u003cp\u003eImmunoglobulin J Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eIGCJ, JCH, Immunoglobulin J chain, IGJ.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174358745172,"sku":"PRO-1420","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174358777940,"sku":"PRO-1420","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174358810708,"sku":"PRO-1420","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-igj-human-PRO-1420.png?v=1776698266"},{"product_id":"igll1-human","title":"IGLL1 Human","description":"\u003cp\u003eImmunoglobulin Lambda-Like Polypeptide 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003e14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2, Immunoglobulin lambda-like polypeptide 1, CD179 antigen-like family member B, Ig lambda-5, Immunoglobulin omega polypeptide, Immunoglobulin-related protein 14.1, IGLL1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174360121428,"sku":"PRO-1390","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174360154196,"sku":"PRO-1390","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174360186964,"sku":"PRO-1390","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-igll1-human-PRO-1390.png?v=1776698276"},{"product_id":"igm-human","title":"IgM Human","description":"\u003cp\u003eImmunoglobulin-M Human\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1mg","offer_id":43174361956436,"sku":"PRO-2745","price":750.0,"currency_code":"USD","in_stock":true},{"title":"5mg","offer_id":43174361989204,"sku":"PRO-2745","price":1950.0,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":43174362021972,"sku":"PRO-2745","price":2950.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-igm-human-PRO-2745.png?v=1776698286"},{"product_id":"igsf8-human","title":"IGSF8 Human","description":"\u003cp\u003eImmunoglobulin Superfamily Member 8 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eImmunoglobulin Superfamily Member 8, Keratinocytes-Associated Transmembrane Protein 4, Glu-Trp-Ile EWI Motif-Containing Protein 2, Prostaglandin Regulatory-Like Protein, CD81 Partner 3, CD81P3, LIR-D1, EWI-2, KCT-4, EWI2, PGRL, Immunoglobulin Superfamily Member 8, CD316 Antigen, CD316, IgSF8, KCT4. \u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174362873940,"sku":"PRO-2451","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174362906708,"sku":"PRO-2451","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174362939476,"sku":"PRO-2451","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-igsf8-human-PRO-2451.png?v=1776698291"},{"product_id":"lilra3-human","title":"LILRA3 Human","description":"\u003cp\u003eLeukocyte Immunoglobulin Like Receptor A3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eLILRA3, ILT6, LIR4, LIR-4, LILRA3, CD85e, Leukocyte immunoglobulin-like receptor subfamily A member 3, leukocyte immunoglobulin-like receptor subfamily A member 3 isoform 1, CD85 antigen-like family member E, Immunoglobulin-like transcript 6, Leukocyte immunoglobulin-like receptor 4, Monocyte inhibitory receptor HM43\/HM31.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174975701076,"sku":"PRO-2831","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174975733844,"sku":"PRO-2831","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174975766612,"sku":"PRO-2831","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lilra3-human-PRO-2831.png?v=1776701550"},{"product_id":"lilrb1-human","title":"LILRB1 Human","description":"\u003cp\u003eLeukocyte Immunoglobulin Like Receptor B1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eLeukocyte immunoglobulin-like receptor subfamily B member 1,Leukocyte immunoglobulin-like receptor 1, leucocyte Ig-like receptor B1, CD85 antigen-like family member J, Immunoglobulin-like transcript 2, myeloid inhibitory receptor 7, Monocyte\/macrophage immunoglobulin-like receptor 7, Ig-like transcript 2, MIR-7, LILRB1, ILT2, LIR1, MIR7, LIR-1, ILT-2, PIRB, PIR-B\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174976684116,"sku":"PRO-2668","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174976716884,"sku":"PRO-2668","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174976749652,"sku":"PRO-2668","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-lilrb1-human-PRO-2668.png?v=1776701556"},{"product_id":"lilrb2-human","title":"LILRB2 Human","description":"\u003cp\u003eLeukocyte Immunoglobulin Like Receptor B2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eLeukocyte Immunoglobulin-like Receptor, CD85D, CD85d, CD85 antigen-like family member D, CD85d antigen, ILT-4, ILT4, ILT4CD85d, Ig-like transcript 4, Immunoglobulin-like transcript 4, LILRB2, LIR2, LIR-2, LIR2CD85D, Leukocyte immunoglobulin-like receptor 2, MIR10, MIR-10, MIR10LILRA6, Monocyte\/macrophage immunoglobulinlike receptor 10, leukocyte immunoglobulin-like receptor subfamily B member 2, leukocyte immunoglobulin-like receptor subfamily B member 2 soluble isoform 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