{"title":"I-309 (CCL1)","description":"\u003ch3 class=\"highlited\"\u003e\n\u003cspan\u003eAbout CCL1\/ I-309:\u003c\/span\u003e \u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism\u003c\/strong\u003e\u003cbr\u003e● CCL1 stands for “chemokine (C-C motif) ligand 1”.\u003cbr\u003e● CCL1 is a small glycoprotein.\u003cbr\u003e● It is secreted by activated T-cells.\u003cbr\u003e● CCL1 belongs to the chemokines family of cytokines. Chemokines are known for their role in the inflammatory response and immunoregulatory processes.\u003cbr\u003e● CCL1 is part of a larger cluster of similar chemokines, which are located on human chromosome 17.\u003cbr\u003e● CCL1 is structurally related to the CXC group of proteins.\u003c\/p\u003e\n\u003cp\u003eCCL1 is also known as:\u003cbr\u003e❖ I-309; T lymphocyte-secreted protein\u003cbr\u003e❖ Inflammatory cytokine I-309\u003cbr\u003e❖ Small inducible cytokine A1\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunction\u003c\/strong\u003e\u003cbr\u003e● CCL1 is considered to be an antimicrobial gene.\u003cbr\u003e● CCL1 has been found present in a number of organs, with the highest presentation found in the colon.\u003cbr\u003e● Other organs where CCL1 is present at significant levels include the brain, the testes, appendix, and gallbladder.\u003cbr\u003e● CCL1 has an established role in cellular aggregate formation in vitro.\u003cbr\u003e● CCL1 has been found in synovial fluids and macrophages in those suffering from juvenile idiopathic arthritis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInteractions\u003c\/strong\u003e\u003cbr\u003e● CCL1 is able to attract a number of cells by interacting with CCR8; a cell surface chemokine receptor.\u003cbr\u003e● The cells that CCL1 attracts include: monocytes, immature B cells, dendritic cells, and NK cells.\u003cbr\u003e● It is notable that the list of cells that experience chemotactic activity does not include neutrophils.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSignificant notes\u003c\/strong\u003e\u003cbr\u003e● Studies have been conducted regarding elevated levels of CCL1 for people suffering from bullous pemphigoid, an ulcerative disorder that is thought to be autoimmune in nature.\u003cbr\u003e● Elevated levels of CCL1 correlate with higher levels of pruritus in patients with cutaneous T-cell lymphoma.\u003cbr\u003e● The interaction of CCL1 with receptor CCR8 have been found to have an influential role in lymphocytic recruitment in IgG4-SC\/AIP. It is believed that this leads to duct-centered inflammation and obliterative phlebitis. This has been noted in patients with type 1 autoimmune pancreatitis.\u003cbr\u003e● Peritoneal adhesions are a significant complication in the aftermath of surgery. Studies have found that Anti-CCL1 mAb or a disruption of the CCR8 receptor has shown decreased peritoneal adhesions.\u003cbr\u003e● CCL1 overexpression has been found to enhance granuloma formation following mycobacterial treatment. It has been speculated this happens due to enhancing endoplasmic reticulum stress.\u003cbr\u003e● It has also been theorized that the activation of CCR8 by its ligand, CCL1, may play an important role in a number of illnesses. Illnesses that may benefit from further investigation into this relationship include asthma, multiple sclerosis, and cancers.\u003c\/p\u003e","products":[{"product_id":"i-309-human","title":"I 309 Human","description":"\u003cp\u003eI-309 Human Recombinant (CCL1)\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSmall inducible cytokine A1, CCL1, T lymphocyte-secreted protein I-309, chemokine (C-C motif) ligand 1, P500, SISe, TCA3, I-309, SCYA1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174239600724,"sku":"CHM-312","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174239633492,"sku":"CHM-312","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174239666260,"sku":"CHM-312","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-i-309-human-CHM-312.png?v=1776697741"},{"product_id":"i-309-human-his","title":"I 309 Human, His","description":"\u003cp\u003eI-309 (CCL1) Human Recombinant, His Tag\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSmall inducible cytokine A1, CCL1, T lymphocyte-secreted protein I-309, chemokine (C-C motif) ligand 1, P500, SISe, TCA3, I-309, SCYA1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174241501268,"sku":"CHM-254","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174241534036,"sku":"CHM-254","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174241566804,"sku":"CHM-254","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-i-309-human-his-CHM-254.png?v=1776697747"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_175269a7-9933-4eb8-84ad-5f8ab74bfad9.png?v=1700647551","url":"https:\/\/prospecbio.com\/collections\/i-309-ccl1.oembed","provider":"prospecbio","version":"1.0","type":"link"}