{"title":"Hypoxia-Inducible Factor","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout HIF1A \/ Hypoxia-Inducible Factor:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eHypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in oxygen levels in the cellular environment, or hypoxia, a medical condition in which the body is deprived of adequate oxygen supply.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eHIF1A Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe alpha subunits of HIF are hydroxylated at conserved proline residues by HIF prolyl-hydroxylases. This allows their recognition and ubiquitination by the VHL E3 ubiquitin ligase, labelling them for rapid degradation by the proteasome. However, this only occurs in normoxic conditions. In comparison, hypoxic conditions cause HIF prolyl-hydroxylase to be inhibited due to using oxygen as a cosubstrate.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eHypoxia-Inducible Factor Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe majority of oxygen-breathing species express the highly conserved transcriptional complex HIF-1. HIF-1 is a heterodimer composed of an alpha and a beta subunit. The beta subunit is a constitutively-expressed aryl hydrocarbon receptor nuclear translocator (ARNT). HIF-1 belongs to the PER-ARNT-SIM (PAS) subfamily of the basic helix-loop-helix (bHLH) family of transcription factors.\u003cbr data-mce-fragment=\"1\"\u003eThe alpha and beta subunits are similar in structure and both contain the following domains:\u003cbr data-mce-fragment=\"1\"\u003e●N-terminus: A bHLH domain for DNA binding\u003cbr data-mce-fragment=\"1\"\u003e●central region: Per-ARNT-Sim (PAS) domain that facilitates heterodimerization\u003cbr data-mce-fragment=\"1\"\u003e●C-terminus: Recruits transcriptional coregulatory proteins\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eHIF1A Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eHIF1α expression in haematopoietic stem cells explains the quiescence nature of stem cells for being metabolically maintaining at a low rate. This preserves the potency of stem cells for long periods in a life cycle of an organism.\u003cbr data-mce-fragment=\"1\"\u003eHIFs are generally vital to development in mammals. If HIF-1 genes are deleted, it results in perinatal death. HIF-1 has also been shown to be vital to chondrocyte survival. This allows the cells to adapt to low-oxygen conditions within the growth plate of bones. Lastly, HIF also plays a central role in regulating the human metabolism\u003c\/p\u003e","products":[{"product_id":"hif1a-human","title":"HIF1A Human","description":"\u003cp\u003eHypoxia-Inducible Factor-1 Alpha Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eHypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43174039257172,"sku":"PRO-477","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174039289940,"sku":"PRO-477","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174039322708,"sku":"PRO-477","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-hif1a-human-PRO-477.png?v=1776697198"},{"product_id":"hif1a-human-85-aa","title":"HIF1A Human (85 a.a.)","description":"\u003cp\u003eHypoxia-Inducible Factor-1 Alpha (85 a.a.) Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eHypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174040174676,"sku":"PRO-258","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174040207444,"sku":"PRO-258","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174040240212,"sku":"PRO-258","price":1100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-hif1a-human-85-aa-PRO-258.png?v=1776697187"},{"product_id":"hif1a-human-his","title":"HIF1A Human, His","description":"\u003cp\u003eHypoxia-Inducible Factor-1 Alpha Human Recombinant,  His Tag\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eHypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174041223252,"sku":"PRO-415","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174041256020,"sku":"PRO-415","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174041288788,"sku":"PRO-415","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-hif1a-human-his-PRO-415.png?v=1776697192"},{"product_id":"hif1an-human","title":"HIF1AN Human","description":"\u003cp\u003eHypoxia-Inducible Factor-1 Alpha Inhibitor Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eFIH1, FIH-1, HIF1AN, Factor Inhibiting HIF1A, Hypoxia-inducible factor 1-alpha inhibitor, Hypoxia-inducible factor asparagine hydroxylase, Factor inhibiting HIF-1, FLJ20615, FLJ22027, DKFZp762F1811.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43174042173524,"sku":"PRO-662","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174042206292,"sku":"PRO-662","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174042239060,"sku":"PRO-662","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-hif1an-human-PRO-662.png?v=1776697203"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_bfa4e892-00a5-4eb7-9437-f7044fdc287e.png?v=1700647526","url":"https:\/\/prospecbio.com\/collections\/hypoxia-inducible-factor.oembed","provider":"prospecbio","version":"1.0","type":"link"}