{"title":"Homer Homolog","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout HOMER \/ Homer Homolog:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eHomer protein homolog 1 is a neuronal protein. In human beings, the HOMER1 gene decodes homer protein homolog 1 (Homer1).\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eHOMER Aliases\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eHomer protein homolog 1 is also known as:\u003cbr data-mce-fragment=\"1\"\u003e●HOMER1\u003cbr data-mce-fragment=\"1\"\u003e●HOMER1A\u003cbr data-mce-fragment=\"1\"\u003e●HOMER1B\u003cbr data-mce-fragment=\"1\"\u003e●HOMER1C\u003cbr data-mce-fragment=\"1\"\u003e●Ves-l\u003cbr data-mce-fragment=\"1\"\u003e●Homer scaffolding protein\u003cbr data-mce-fragment=\"1\"\u003e●PSD-Zip45\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eHomer Homolog Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eHomer1 protein has two terminal domains: the N-terminal EVH1 domain is involved in protein interaction and the C-terminal coiled-coil domain is involved in self-association. There are two primary splice variants: these are short-form, known as Homer1a, and long-form, known as Homer1b and Homer1c. In the Homer1a variant, there is only an EVH1 domain. The long-form variants have both EVH1 and coiled-coil domains. The coiled-coil can be broken down further into two halves, the N-terminal and the C-terminal.\u003cbr data-mce-fragment=\"1\"\u003eWhen examined as a whole, the long-form Homer1 protein is said to resemble a dumbbell with two EVH1 domains positioned at the end of a coiled-coil domain.\u003cbr data-mce-fragment=\"1\"\u003eMammals have Homer2 and Homer3 proteins, as well as Homer1.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eHOMER Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eHomer1 is expressed predominantly in the central nervous system, as well as within periphery tissue, including the kidneys, ovaries, testes, skeletal muscle and heart. Homer1 proteins work like scaffolding that forms clusters. This protein is involved in linking metabotropic glutamate receptors to other effectors to regulate the activity of mGluR.\u003cbr data-mce-fragment=\"1\"\u003eEVH1 domain interacts with PPXXF, which is found in a host of receptors, including group 1 metabotropic glutamate receptor, IP3 receptors, Shank, transient receptor potential canonical family channels, ryanodine receptors, drebrin and dynamin3. Long-form Homer1 proteins cross-link different proteins.\u003cbr data-mce-fragment=\"1\"\u003eNeuronal activity triggers the expression of Homer1a while Homer1b and Homer1c are constitutive. Homer1a is known as an immediate early gene and it can perform as a negative actor that blocks interaction between long-forms and their ligand proteins. Short-form Homer1 protein is therefore able to shrink dendritic structure. It is also part of the mechanism of homeostatic plasticity, which reduces activity when input rises too steeply. Coiled-coil interaction with Cdc42 prevents Cdc42 activity to reform dendritic spine structure.\u003c\/p\u003e","products":[{"product_id":"homer1-human","title":"HOMER1 Human","description":"\u003cp\u003eHomer Homolog-1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eHOMER, SYN47, Ves-1, HOMER1A, HOMER1B, HOMER1C, HOMER1, Homer protein homolog 1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174137790548,"sku":"PRO-695","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174137823316,"sku":"PRO-695","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174137856084,"sku":"PRO-695","price":3000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-homer1-human-PRO-695.png?v=1776443284"},{"product_id":"homer2-human","title":"HOMER2 Human","description":"\u003cp\u003eHomer Homolog-2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eHomer homolog 2 (Drosophila), homer neuronal immediate early gene 2, homer homolog 3, HOMER-2 (2A\/2B), Vesl-2, ACPD, Cupidin, CPD.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174138609748,"sku":"PRO-1072","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174138642516,"sku":"PRO-1072","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174138675284,"sku":"PRO-1072","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-homer2-human-PRO-1072.png?v=1776443288"},{"product_id":"homer3-human","title":"HOMER3 Human","description":"\u003cp\u003eHomer Homolog-3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eHomer homolog 3 (Drosophila)1 2 , HOMER-31 2 , homer protein homolog 32 , Homer neuronal immediate early gene 32, Homer-33, VESL32.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174139461716,"sku":"PRO-1108","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174139494484,"sku":"PRO-1108","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174139527252,"sku":"PRO-1108","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-homer3-human-PRO-1108.png?v=1776443293"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_bb4204d3-ed01-462c-925e-bf1b85855a7a.png?v=1700647537","url":"https:\/\/prospecbio.com\/collections\/homer-homolog.oembed","provider":"prospecbio","version":"1.0","type":"link"}