{"title":"HLA","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout HLA \/ Human leukocyte antigen:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eHLA - or human leukocyte antigen - is a set of genes that encodes for proteins on cells’ surfaces that regulate the function of the immune system. The human version of the gene complex is the analogue to the animal version of the MHC (major histocompatibility complex class).\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eHLA Functions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eHLAs are implicated in a range of functions in the human body. For instance, in infectious diseases, certain immune cells break down antigen-presenting cells via phagocytosis and break them into small pieces. HLAs antigens are then displayed to CD4+ helper T cells when then create the various effects to eliminate the pathogen.\u003cbr data-mce-fragment=\"1\"\u003eIn autoimmunity, HLA types are associated with certain autoimmune diseases, including rheumatoid arthritis, type 1 diabetes, and celiac disease. Now that researchers more fully understand HLA types, it is becoming easier for them to diagnose specific diseases, such as type 1 diabetes and celiac.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eHuman leukocyte antigen Classification\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eResearchers segment HLA into three major MHC subgroups: HLA-A, HLA-B,, and HLA-C - as well as some minor genes.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eHLA Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eHLA loci, like many MHC loci across mammals, have highly variable genetic coding. Over the eons, HLA loci survived the constriction with resulting high variable structures. HLA loci are among the fastest-evolving in the human genome. Many remote tribes isolated from the global population have undergone profound gene conversion between the loci and alleles within each HLA gene class.\u003cbr data-mce-fragment=\"1\"\u003eIn total, six loci have more than 100 alleles detected across the total human population. Currently, the most variable is HLA-B and HLA DRB1. The high variability of HLA genes makes it difficult to study their role in disease.\u003c\/p\u003e","products":[{"product_id":"hla-c-human","title":"HLA-C Human","description":"\u003cp\u003eMajor Histocompatibility Complex Class I C Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eMajor Histocompatibility Complex Class I- C, D6S204, HLA-JY3, PSORS1, HLC-C, HLA Class I Histocompatibility Antigen C Alpha Chain, Human Leukocyte Antigen-C Alpha Chain, Major Histocompatibility Antigen HLA-C, MHC Class I Antigen Heavy Chain 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IIHLA-DRw10-Beta.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174111969364,"sku":"PRO-1888","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174112002132,"sku":"PRO-1888","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174112034900,"sku":"PRO-1888","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-hla-drb1-human-PRO-1888.png?v=1776443195"},{"product_id":"hla-drb1","title":"HLA-DRB1 Human, Sf9","description":"\u003cp\u003eMajor Histocompatibility Complex Class II DR Beta 1 Human Recombinant, Sf9\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eDRB1, HLA DRB1, HLA-DR1B, HLA-DRB1, MHC class II antigen DRB1 16, DR-16, DR16, Human Leucocyte Antigen DRB1, MHC Class II HLA-DR-Beta Cell Surface Glycoprotein, MHC Class II 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