{"title":"Guanine Nucleotide Binding Protein","description":"\u003ch2 class=\"highlited\"\u003e\u003cspan\u003eAbout Guanine Nucleotide Binding Protein:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003eGuanine nucleotide-binding proteins, otherwise known simply as G proteins, were discovered in 1994 by Alfred G. Gilman and Martin Rodbell. They are a family of proteins that function as signal transducing molecules and molecular switches that transmit signals from stimuli found outside the cell to the inner cells by activating the heptahelical receptors to mediate a physiological response.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGuanine Nucleotide Binding Protein Structure\u003c\/strong\u003e\u003cbr\u003eG proteins consist of three subunits, Alpha, Beta, and Gamma. The human body encodes 18 Gα proteins, 5 Gβ proteins, and 12 Gγ proteins while G proteins are separated into large G proteins (Heterotrimeric G proteins) and small G proteins. Large G proteins are activated by the body’s G protein receptors and are inactivated by Regulator of G protein Signalling.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGuanine Nucleotide Binding Protein Function\u003c\/strong\u003e\u003cbr\u003eBoth large and small G proteins bind and hydrolyze via guanosine triphosphate (GTP) to guanosine diphosphate (GDP).\u003cbr\u003eMalfunctions of the G protein-coupled receptors play a significant role in the development of various cancers, as well as diabetes, blindness, cardiovascular problems, and depression.\u003cbr\u003eG Alpha proteins activate the The cAMP-dependent pathway and stimulate the cyclic AMP, thus becoming a signal transducing pathway for ADH, GHRH, GHIH, CRH, TSH, LH, Glucagon, hCG, and other naturally-occurring hormones.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGuanine Nucleotide Binding Protein Mechanism\u003c\/strong\u003e\u003cbr\u003eThe mechanisms activate receptors by ligand to exchange the GDP and GTP before activating an effector, which will determine the lifetime of the guanine nucleotide-binding protein’s lifetime. GDP is released from the effector in the post-hydrolyzing status to restore the heterotrimeric GDP and interact with the membrane receptors before reinitiating the cycle.\u003cbr\u003eG proteins regulate metabolic enzymes, ion channels, and transporter proteins while additional controlling motility and secretion.\u003c\/p\u003e","products":[{"product_id":"gnai1-human","title":"GNAI1 Human","description":"\u003cp\u003eGuanine Nucleotide Binding Protein Alpha Inhibiting Activity 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eGuanine nucleotide-binding protein G(i) subunit alpha-1, Adenylate cyclase-inhibiting G alpha protein, GNAI1, Gi.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174976782420,"sku":"PRO-940","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174976815188,"sku":"PRO-940","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174976847956,"sku":"PRO-940","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gnai1-human-PRO-940.png?v=1776695728"},{"product_id":"gnai3-human","title":"GNAI3 Human","description":"\u003cp\u003eGuanine Nucleotide Binding Protein Alpha Inhibiting Activity 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eGuanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3, G(i) alpha-3, 87U6.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174978322516,"sku":"PRO-1074","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174978355284,"sku":"PRO-1074","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174978388052,"sku":"PRO-1074","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gnai3-human-PRO-1074.png?v=1776695738"},{"product_id":"gnaz-human","title":"GNAZ Human","description":"\u003cp\u003eGuanine Nucleotide Binding Protein Alpha Z Polypeptide Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eGuanine Nucleotide Binding Protein (G Protein) Alpha Z Polypeptide, G(X) Alpha Chain, Guanine Nucleotide-Binding Protein G(Z) Subunit Alpha, Gz-Alpha, Transducin Alpha.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174980386900,"sku":"PRO-1225","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174980419668,"sku":"PRO-1225","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174980452436,"sku":"PRO-1225","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gnaz-human-PRO-1225.png?v=1776695747"},{"product_id":"gnb1-human","title":"GNB1 Human","description":"\u003cp\u003eGuanine Nucleotide Binding Protein Beta Polypeptide 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eGuanine Nucleotide Binding Protein (G Protein) Beta Polypeptide 1, Transducin Beta Chain 1, GNB1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174981075028,"sku":"PRO-1955","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174981107796,"sku":"PRO-1955","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174981140564,"sku":"PRO-1955","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gnb1-human-PRO-1955.png?v=1776695752"},{"product_id":"gnb2l1-human","title":"GNB2L1 Human","description":"\u003cp\u003eGuanine Nucleotide Binding Protein beta polypeptide 2-like 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eGuanine nucleotide binding protein (G protein) beta polypeptide 2-like 1, RACK1, Receptor for Activated C Kinase 1, Gnb2-rs1, H12.3, Cell proliferation-inducing gene 21 protein, Guanine nucleotide-binding protein subunit beta-like protein 12.3, Human lung cancer oncogene 7 protein, Receptor of activated protein kinase C 1, HLC-7, PIG21, proliferation-inducing gene 21, protein homologous to chicken B complex protein guanine nucleotide binding.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174982025300,"sku":"PRO-1023","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174982058068,"sku":"PRO-1023","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174982090836,"sku":"PRO-1023","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gnb2l1-human-PRO-1023.png?v=1776695757"},{"product_id":"gnb3-human","title":"GNB3 Human","description":"\u003cp\u003eGuanine Nucleotide Binding Protein Beta Polypeptide 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eTransducin Beta Chain 3, G Protein, Beta-3 Subunit, GTP-Binding\nRegulatory Protein Beta-3 Chain, Guanine Nucleotide-Binding Protein\nG(I)\/G(S)\/G(T) Beta Subunit 3, Guanine Nucleotide-Binding Protein\nG(I)\/G(S)\/G(T) Subunit Beta-3, Hypertension Associated Protein, Guanine\nNucleotide Binding Protein (G Protein), Beta Polypeptide 3, GNB3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174982910036,"sku":"PRO-332","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174982942804,"sku":"PRO-332","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174982975572,"sku":"PRO-332","price":3600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gnb3-human-PRO-332.png?v=1776695762"},{"product_id":"gng11-human","title":"GNG11 Human","description":"\u003cp\u003eGuanine Nucleotide Binding Protein Gamma 11 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eGNGT11, Guanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-11, GNG11.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174983827540,"sku":"PRO-1854","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174983860308,"sku":"PRO-1854","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174983893076,"sku":"PRO-1854","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gng11-human-PRO-1854.png?v=1776695766"},{"product_id":"gng12-human","title":"GNG12 Human","description":"\u003cp\u003eGuanine Nucleotide Binding Protein Gamma 12 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eGuanine Nucleotide Binding Protein (G Protein), Gamma 12,\nGuanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-12.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174984482900,"sku":"PRO-2184","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174984515668,"sku":"PRO-2184","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174984548436,"sku":"PRO-2184","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gng12-human-PRO-2184.png?v=1776695772"},{"product_id":"gng13-human","title":"GNG13 Human","description":"\u003cp\u003eGuanine Nucleotide Binding Protein Gamma 13 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eGuanine Nucleotide Binding Protein (G Protein), Gamma 13,\nClone:H2-35, G Gamma Subunit, G(gamma)13, Guanine Nucleotide Binding Protein 13, Gamma,\nGuanine Nucleotide-Binding Protein G(I)\/G(S)\/G(O)\nSubunit Gamma-13 h2-35, G Gamma Subunit,\nclone:h2-35, GNG13.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174985236564,"sku":"PRO-2063","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174985269332,"sku":"PRO-2063","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174985302100,"sku":"PRO-2063","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gng13-human-PRO-2063.png?v=1776695776"},{"product_id":"gng4-human","title":"GNG4 Human","description":"\u003cp\u003eGuanine Nucleotide Binding Protein Gamma 4 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eGuanine Nucleotide Binding Protein (G Protein) Gamma 4, Guanine Nucleotide-Binding Protein G(I)\/G(S)\/G(O) Subunit Gamma-4, GNGT4.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174986252372,"sku":"PRO-1842","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174986285140,"sku":"PRO-1842","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174986317908,"sku":"PRO-1842","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gng4-human-PRO-1842.png?v=1776695781"},{"product_id":"gngt1-human","title":"GNGT1 Human","description":"\u003cp\u003eGuanine Nucleotide Binding Protein Gamma Transducing 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eGuanine\nNucleotide Binding Protein (G Protein), Gamma Transducing Activity Polypeptide\n1, Transducin Gamma Chain, Guanine Nucleotide-Binding Protein G(T) Subunit\nGamma-T1, GNG1, Guanine nucleotide-binding protein G(T) subunit gamma-T1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174987169876,"sku":"PRO-2084","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174987202644,"sku":"PRO-2084","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174987235412,"sku":"PRO-2084","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gngt1-human-PRO-2084.png?v=1776695786"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_f89a02e1-a2bd-418a-b23b-42f67fd7ec97.png?v=1700647481","url":"https:\/\/prospecbio.com\/collections\/guanine-nucleotide-binding-protein.oembed","provider":"prospecbio","version":"1.0","type":"link"}