{"title":"General Transcription Factor","description":"\u003ch2 class=\"highlited\"\u003e\u003cspan\u003eAbout GTF \/ General Transcription Factor:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003eGeneral transcription factors, or GTFs, are a class of protein transcription factors. These factors bind to sites on the DNA and activate communication between the DNA and messengers such as RNA. These specific sites are also called promoters. The GTF, RNA and Polymerase form the foundation for transcriptional following the initial promoter bind.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGTF Mechanism\u003c\/strong\u003e\u003cbr\u003eGTFs also play a key role in gene regulation and are a vital component of life. A transcription factor is a protein contained in the GTF class. It binds to sequences of DNA alone or with other proteins. This binding regulates the flow of transcription information from DNA to the RNA messenger.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGeneral Transcription Factor Function\u003c\/strong\u003e\u003cbr\u003eThis protein can serve as an activator or a blocker. It operates in a large complex of genetic interactions to repress or encourage the recruitment of RNA polymerase. GTFs are General factors that bind to promoters on the DNA sequence. They link up with other proteins to form large transcriptional complexes needed to activate transcription.\u003cbr\u003eThe function and mechanism of GTFs differ depending on the DNA and RNA. In bacteria, initiation on the RNA synthesis sequence is carried out by a sigma factor. These provide effective recognition of RNA polymerase and assist with DNA stand separation. They subsequently separated from the RNA core enzyme.\u003cbr\u003eIn archaea and eukaryotes, the function and mechanism are slightly different. The transcription preinitiation complex is a line of proteins necessary for transcribing the protein code genes of eukaryotes and archaea. The GTF attaches to the promoter and initiates the RNA polymerase at the gene transcription site.\u003c\/p\u003e","products":[{"product_id":"gtf2a1-human","title":"GTF2A1 Human","description":"\u003cp\u003eGeneral Transcription Factor IIA, 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eGeneral transcription factor IIA, 1, 19\/37kDa, TF2A1, TFIIA, TFIIA-42, TFIIAL, Transcription initiation factor IIA subunit 1, Transcription initiation factor TFIIA 42 kDa subunit, GTF2A1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175101595732,"sku":"PRO-1808","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175101628500,"sku":"PRO-1808","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175101661268,"sku":"PRO-1808","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gtf2a1-human-PRO-1808.png?v=1776696521"},{"product_id":"gtf2b-human","title":"GTF2B Human","description":"\u003cp\u003eGeneral Transcription Factor IIB Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eTF2B, TFIIB, GTF2B, Transcription initiation factor IIB, General transcription factor TFIIB, S300-II.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175102546004,"sku":"PRO-762","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43175102578772,"sku":"PRO-762","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175102611540,"sku":"PRO-762","price":2250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gtf2b-human-PRO-762.png?v=1776696525"},{"product_id":"gtf2e2-human","title":"GTF2E2 Human","description":"\u003cp\u003eGeneral Transcription Factor IIE, Polypeptide 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eGeneral transcription factor IIE polypeptide 2 beta 34kDa, transcription initiation factor IIE subunit beta, TFIIE-beta, TF2E2, TFIIE-B.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175103627348,"sku":"PRO-1107","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175103660116,"sku":"PRO-1107","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175103692884,"sku":"PRO-1107","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gtf2e2-human-PRO-1107.png?v=1776696530"},{"product_id":"gtf2f2-human","title":"GTF2F2 Human","description":"\u003cp\u003eGeneral Transcription Factor IIF, Polypeptide 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eGeneral transcription factor IIF subunit 2, ATP-dependent helicase GTF2F2, General transcription factor IIF 30 kDa subunit, Transcription initiation factor IIF subunit beta, TFIIF-beta, Transcription initiation factor RAP30, GTF2F2, RAP30, BTF4, TF2F2, TFIIF.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175104479316,"sku":"PRO-1093","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175104512084,"sku":"PRO-1093","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175104544852,"sku":"PRO-1093","price":3600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gtf2f2-human-PRO-1093.png?v=1776696535"},{"product_id":"gtf2h5-human","title":"GTF2H5 Human","description":"\u003cp\u003eGeneral Transcription Factor IIH Polypeptide 5 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eGeneral transcription factor IIH subunit 5, bA120J8.2,\nC6orf175, TFB5, TFIIH, TGF2H5, TTD, TTD-A, TTDA, TFIIH basal transcription\nfactor complex TTD-A subunit, TFB5 ortholog.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175105462356,"sku":"PRO-2125","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175105495124,"sku":"PRO-2125","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175105527892,"sku":"PRO-2125","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gtf2h5-human-PRO-2125.png?v=1776696540"},{"product_id":"gtf3c6-human","title":"GTF3C6 Human","description":"\u003cp\u003eGeneral Transcription Factor IIIC Polypeptide 6 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003ebA397G5.3, C6orf51, TFIIIC35, General transcription\nfactor 3C polypeptide 6, Transcription factor IIIC 35 kDa subunit, TFIIIC 35\nkDa subunit, TFIIIC35, Transcription factor IIIC subunit 6, CDA020, NPD020.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43175106150484,"sku":"PRO-2127","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43175106183252,"sku":"PRO-2127","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175106216020,"sku":"PRO-2127","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gtf3c6-human-PRO-2127.png?v=1776696545"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_c0e6ce30-16f2-4031-807f-dcb33d2ba60a.png?v=1700647496","url":"https:\/\/prospecbio.com\/collections\/general-transcription-factor.oembed","provider":"prospecbio","version":"1.0","type":"link"}