{"title":"Fragile Histidine Triad","description":"\u003ch2 class=\"highlited\"\u003e\u003cspan\u003eAbout FHIT \/ Fragile Histidine Triad:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003eThe fragile histidine triad protein (FHIT) enzyme is encoded by the FHIT gene in humans. It is also known as the human accelerated region and may have played an important role in distinguishing humans from apes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFHIT Expression\u003c\/strong\u003e\u003cbr\u003eThe FHIT protein is a tumor suppressor that is expressed infrequently or not at all in many forms of cancer. FHIT expression is more commonly lost in cancers of people with familial mutations that cause deficiencies in DNA repair genes including BRCA1 and BRCA2 as well as MSH2.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFragile Histidine Triad Function\u003c\/strong\u003e\u003cbr\u003eIn vitro, FHIT acts as a hydrolase, converting adenosine triphosphate (Ap3A) to ADP and AMP. The tumor suppressor signal appears to be the FHIT-Ap3A enzyme-substrate complex. In cancer-derived cells and tumor xenografts, restoring FHIT expression in FHIT-deficient cancer cells triggers apoptosis via the intrinsic caspase pathway.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFHIT Family\u003c\/strong\u003e\u003cbr\u003eFHIT is a member of the broad HIT family of proteins characterized by the histidine triad motif, HxHxHxx, and is comparable to a yeast enzyme, diadenosine tetraphosphate (Ap4A) hydrolase (where x is a hydrophobic residue).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFragile Histidine Triad Structure\u003c\/strong\u003e\u003cbr\u003eThe FHIT gene stretches over 1.6 Mb of genomic DNA and is made up of ten exons.\u003cbr\u003eThe FHIT gene encodes a 1.1 kb mRNA that is generated at low levels in the majority of tissues. FHIT includes the common fragile site FRA3B, where carcinogen-induced damage may result in deletions, translocations, and erroneous transcripts. This gene's erroneous transcripts have been detected in about half of all esophageal carcinomas, stomach carcinomas, and other carcinomas. On chromosome 1, there is a pseudogene with sequences that are almost similar to the 5'UTR of FHIT.\u003c\/p\u003e","products":[{"product_id":"fhit-human","title":"FHIT Human","description":"\u003cp\u003eFragile Histidine Triad Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eEC 3.6.1.29, Dinucleosidetriphosphatase, Bis (5''-adenosyl)-triphosphatase , AP3Aase, AP3A hydrolase, Diadenosine 5'',5''''''-P1,P3-triphosphate hydrolase, FRA3B.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174653034580,"sku":"PRO-828","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43174653067348,"sku":"PRO-828","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174653100116,"sku":"PRO-828","price":2250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-fhit-human-PRO-828.png?v=1776694230"},{"product_id":"fhit-human-gst","title":"FHIT Human, GST","description":"\u003cp\u003eFragile Histidine Triad Human Recombinant, GST Tag\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eBis(5'-adenosyl)-triphosphatase, EC 3.6.1.29, Diadenosine 5',5'''-P1,P3-triphosphate hydrolase, Dinucleosidetriphosphatase, AP3A hydrolase, AP3Aase, Fragile histidine triad protein, FHIT, FRA3B.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174653886548,"sku":"PRO-297","price":175.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174653919316,"sku":"PRO-297","price":270.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174653952084,"sku":"PRO-297","price":490.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-fhit-human-gst-PRO-297.png?v=1776694225"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_19723c0c-4341-4d61-800b-37948fe004c1.png?v=1700646722","url":"https:\/\/prospecbio.com\/collections\/fragile-histidine-triad.oembed","provider":"prospecbio","version":"1.0","type":"link"}