{"title":"FK506 Binding Protein","description":"\u003ch3 class=\"highlited\"\u003e\u003cspan\u003eAbout FK506 Binding Protein \\ FKBP:\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003eFK506 Binding Protein is related to the cyclophilins in terms of function, although they do not share the same amino acid sequence. Sometimes referred to as FKBP, FK506 binding protein is a member of the immunophilin family and has been shown to exist in various eukaryotes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFK506 Binding Protein Mechanisms\u003c\/strong\u003e\u003cbr\u003eFKBP refers to a number of different binding proteins, which may have different mechanisms of action. However, the FK506 binding protein has been shown to act as molecular switches by binding directly to their target proteins and altering their shape and structure. For example, the FKBP12-FK506 complex is created when FK506 binds to cytosolic FKBP12.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFKBP Function\u003c\/strong\u003e\u003cbr\u003eFK506 binding proteins have a number of functions, some of which are still emerging. Within the FK506 binding proteins family, FKBP12 is known to bind with immunosuppressant drugs, Rapamycin, and Tacrolimus (also known as FK506). Operating as a cis\/trans peptidyl prolyl isomerase (PPIase), FKBP12 then begins the process of interconversion between prolyl cis\/trans conformations.With a range of functions, FKBPs are involved in protein folding, apoptosis, cellular functioning, and transcription. Due to their varied functions, studies have suggested that FKBPs may be involved with the regulation of cardiac function, immunosuppression, neurodegenerative diseases, cancer, neuronal development, and function, as well as heart disease.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFK506 Binding Protein Structure\u003c\/strong\u003e\u003cbr\u003eWith the FK506 binding proteins family, FKBP12 is expressed in all types of tissues and has been identified as a 12 kDa cytosolic protein. FKBP38 contains 413 amino acids and has a predicted size of 45 kDa, however, there have been some discrepancies over the exact structure of FKBP38 in the past. Residing in both the nucleus and cytoplasm, FKBP52 is a co-chaperone of heat-shock protein 90 (Hsp90) and has an active role in steroid receptor regulation. Sharing 60% of sequencing homology with FKBP52, FKBP51 also features Ca2+\/CaM binding motif, three TPR domains and two PPIase domains.\u003cbr\u003eIn contrast, FKBP36 lacks PPIase activity but contains a C-terminal TPR domain and an N-terminal PPIase domain. Whilst FKBP36 lacks PPIase activity, it remains able to bind with various proteins due to its TPR and PPIase domains. FKBP57 also contains a TPR domain at its C-terminus, as well as a PPIase domain at its N-terminus. Defined as an aryl hydrocarbon receptor-interacting protein, FKBP57 doesn’t exhibit PPIase activity, nor does it bind to FK506. However, its structure does enable it to interact with Hsp90 via its TPR and PPIase domains.\u003cbr\u003eIn addition to this, FKBPP25 features a nuclear targeting sequence and includes a PPIase domain at its C-terminus and a hydrophilic helix-loop-helix (HLH) motif at its N-terminus. Finally, FKBP133, sometimes known as WAFL, is comprised of a PPIase domain and a Wiskott-Aldrich syndrome protein homology region1(WH1).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFKBP Interactions\u003c\/strong\u003e\u003cbr\u003eTPR domains are commonly involved in mediating protein-protein interactions, which means many of the proteins within the FK506 family work in this way. In relation to immunosuppression, the FK506-FKBP12 complex interacts with calcineurin (CaN), which is a Ca2+-dependent serine-threonine phosphatase. When present in muscle cells, FKBP12 has been shown to interact with the Ca2+ release channels of the sarcoplasmic reticulum (SR) ryanodine receptors (RyRs), whilst FKBP57 interacts with hsp90 via both PPIase and TPR domains.\u003c\/p\u003e","products":[{"product_id":"fkbp14-human","title":"FKBP14 Human","description":"\u003cp\u003eFK506 Binding Protein 14 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eFKBP22, FKBP-14, FK506 Binding Protein 14, FKBP14, EC=5.2.1.8, PPlase FKBP14,  Peptidyl-prolyl cis-trans isomerase FKBP14, FLJ20731.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174667550804,"sku":"ENZ-530","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43174667583572,"sku":"ENZ-530","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174667616340,"sku":"ENZ-530","price":2250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-fkbp14-human-ENZ-530.png?v=1776694295"},{"product_id":"fkbp1a-human","title":"FKBP1A Human","description":"\u003cp\u003eFK506 Binding Protein 1A Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eFKBP12, PPIase, Peptidyl-prolyl cis-trans isomerase, Rotamase, FKBP-12, FKBP1, PKC12, PKCI2, FKBP12C, FKBP1A, PPIase FKBP1A, FK506-binding protein 1A, 12 kDa FKBP, FKBP-1A.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174668337236,"sku":"ENZ-374","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174668370004,"sku":"ENZ-374","price":145.0,"currency_code":"USD","in_stock":true},{"title":"0.1mg","offer_id":43174668402772,"sku":"ENZ-374","price":400.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-fkbp1a-human-ENZ-374.png?v=1776694299"},{"product_id":"fkbp1a-mouse","title":"FKBP1A Mouse","description":"\u003cp\u003eFK506 Binding Protein 1A Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003ePeptidyl-prolyl cis-trans isomerase FKBP1A, PPIase FKBP1A, 12 kDa FK506-binding protein, 12 kDa FKBP, FKBP-12, Calstabin-1, FK506-binding protein 1A, FKBP-1A, Immunophilin FKBP12, Rotamase, Fkbp1, FKBP1A.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174669353044,"sku":"ENZ-871","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174669385812,"sku":"ENZ-871","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174669418580,"sku":"ENZ-871","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-fkbp1a-mouse-ENZ-871.png?v=1776694304"},{"product_id":"fkbp1b-human","title":"FKBP1B Human","description":"\u003cp\u003eFK506 Binding Protein 1B Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003ePeptidyl-prolyl cis-trans isomerase FKBP1B, PPIase FKBP1B, 12.6 kDa FK506-binding protein, 12.6 kDa FKBP, FKBP-12.6, FK506-binding protein 1B, FKBP-1B, Immunophilin FKBP12.6, Rotamase, h-FKBP-12, FKBP1B, FKBP12.6, FKBP1L, FKBP9, OTK4.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174670368852,"sku":"ENZ-194","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174670401620,"sku":"ENZ-194","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174670434388,"sku":"ENZ-194","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-fkbp1b-human-ENZ-194.png?v=1776694308"},{"product_id":"fkbp2-human","title":"FKBP2 Human","description":"\u003cp\u003eFK506 Binding Protein 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eFKBP13, FKBP-2, Peptidyl-prolyl cis-trans isomerase FKBP2, PPIase FKBP2, FK506-binding protein 2, Rotamase, Immunophilin FKBP13, 13 kDa FK506-binding protein, 13 kDa FKBP, FKBP-13, FKBP2, PPIase.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174671220820,"sku":"ENZ-503","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174671253588,"sku":"ENZ-503","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174671286356,"sku":"ENZ-503","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-fkbp2-human-ENZ-503.png?v=1776694312"},{"product_id":"fkbp3-human","title":"FKBP3 Human","description":"\u003cp\u003eFK506 Binding Protein 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eEC 5.2.1.8, FKBP-3, FKBP25, FKBP-25, Peptidyl-prolyl cis-trans isomerase FKBP3, PPIase FKBP3, FK506-binding protein 3, Rotamase, Immunophilin FKBP25, 25 kDa FK506-binding protein, 25 kDa FKBP, Rapamycin-selective 25 kDa immunophilin, FKBP3, PPIase.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174672236628,"sku":"ENZ-495","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174672269396,"sku":"ENZ-495","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174672302164,"sku":"ENZ-495","price":2250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-fkbp3-human-ENZ-495.png?v=1776694317"},{"product_id":"fkbp4-human","title":"FKBP4 Human","description":"\u003cp\u003eFK506 Binding Protein 4 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eHBI, p52, Hsp56, FKBP52, FKBP59, PPIase, FKBP4, FK506-binding protein 4, Peptidyl-prolyl cis-trans isomerase, HSP-binding immunophilin, FKBP52 protein, 52 kDa FK506-binding protein, p59 protein.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43174674169940,"sku":"ENZ-412","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174674202708,"sku":"ENZ-412","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174674235476,"sku":"ENZ-412","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-fkbp4-human-ENZ-412.png?v=1776694325"},{"product_id":"fkbp5-human","title":"FKBP5 Human","description":"\u003cp\u003eFK506 Binding Protein 5 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eFK506 Binding Protein 5, 54 KDa Progesterone Receptor-Associated Immunophilin, 51 KDa FK506-Binding Protein, Androgen-Regulated Protein 6, HSP90-Binding Immunophilin, FK506-Binding Protein 5, PPIase FKBP5, 51 KDa FKBP, FF1 Antigen, EC 5.2.1.8, Rotamase, FKBP-51, FKBP51, FKBP54, AIG6, P54, Peptidylprolyl Cis-Trans Isomerase, T-Cell FK506-Binding Protein, PPIASE, Ptg-10, FKBP-5, FKBP5.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174674858068,"sku":"ENZ-939","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174674890836,"sku":"ENZ-939","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174674923604,"sku":"ENZ-939","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-fkbp5-human-ENZ-939.png?v=1776694329"},{"product_id":"fkbp6-human","title":"FKBP6 Human","description":"\u003cp\u003eFK506 Binding Protein 6 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eFKBP36, EC 5.2.1.8, FKBP-6, PPIase, MGC87179, FK506-binding protein 6, Rotamase.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174676660308,"sku":"ENZ-516","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174676693076,"sku":"ENZ-516","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174676725844,"sku":"ENZ-516","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-fkbp6-human-ENZ-516.png?v=1776694338"},{"product_id":"fkbpl-human","title":"FKBPL Human","description":"\u003cp\u003eFK506 Binding Protein Like Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eWISP39, DIR1, NG7, FK506-binding protein-like, WAF-1\/CIP1 stabilizing protein 39, FKBPL.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174677381204,"sku":"ENZ-543","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174677413972,"sku":"ENZ-543","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174677446740,"sku":"ENZ-543","price":1100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-fkbpl-human-ENZ-543.png?v=1776694342"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_5d1381a0-c2cd-41c8-90cf-a348eb49e98e.png?v=1700646727","url":"https:\/\/prospecbio.com\/collections\/fk506-binding-protein.oembed","provider":"prospecbio","version":"1.0","type":"link"}