{"title":"FAS","description":"\u003ch3 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout FAS Ligand:\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp data-mce-fragment=\"1\"\u003eFas ligand (FasL or CD95L) is a type two transmembrane protein that is part of the tumor necrosis factor (TNF) group. When it binds to its receptor, it starts apoptosis. The Fas ligand and receptor interactions play a vital role in the regulation of the immune system and the progression of various cancers.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eStructure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eFasL is what is called a homotrimeric type two transmembrane protein, which is expressed on cytotoxic T lymphocytes. It creates signals through trimerization of FasR, spamming the membrane of the target cell. This process of trimerization either leads to apoptosis or death of the cell. The process of creating soluble Fas ligand is created by cleaving membrane-bound FasL at a conserved cleavage site via external matrix metalloproteinase, known as MMP-7.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eFunction\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe process of apoptosis, which is triggered by Fas-Fas ligand binding, plays a major role in the regulation of the human immune system. Its functions include the following:\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e● T-cell homeostasis, which is the activation of T-cells which lead the expression of the Fas ligand. These T-cells start out resistant to Fas-mediated apoptosis but become increasingly more sensitive the longer they are active for, which can often result in the activation-induced death of the cell. This process is used to prevent an excessive immune system response, eliminating autoreactive T-cells. Many people with deleterious mutations of Fas ligand, go onto develop a build-up of T-cells, which can lead to lymphadenopathy, splenomegaly, and lupus.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e● Cytotoxic T-cell activity is Fas-induced apoptosis, with the perforin pathway being the two main mechanisms of which cytotoxic T lymphocytes cause cell death in cells that are expressing foreign antigens.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e● Immune privilege is when cells in immune privileged areas, like the testes or cornea, express Fas ligand and cause the apoptosis of infiltrating lymphocytes. This is one of many of the body’s mechanisms used to establish and maintain the power of immune privilege.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e● Maternal tolerance is when Fas ligand may be able to prevent leukocyte trafficking between a mother and baby, despite the fact that no birth defects have been attributed to a faulty Fas ligand system.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e● Tumor counter attack: tumors sometimes over-express Fas ligand and cause the apoptosis of infiltrating lymphocytes, which allows the tumor to escape the effects of an immune response. This up-regulation of Fas ligand can occur after chemotherapy, due to which the tumor cells attain apoptosis resistance.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eMechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eFas creates the death-inducing signalling complex known as DISC when ligand binding occurs. Membrane connectected Fas ligand trimer on the surface of an adjacent cell can cause trimerization of Fas receptor. This can also be mimicked by the binding of an agonistic Fas antibody. Although some evidence does suggest that the apoptotic signal created by the antibody is unreliable when it comes to Fas signalling. Because of this, various ways of trimerized an antibody for in vitro research have been put into action. When it enters DD (death domain), the receptor complex is internalized via cellular endosomal machinery. This gives the adaptor molecule FADD to bind the death domain of Fas through its own domain.\u003c\/p\u003e","products":[{"product_id":"fas-human","title":"FAS Human","description":"\u003cp\u003esFas Receptor Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eTumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, CD95, FAS, APT1, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174545981524,"sku":"CYT-125","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174546014292,"sku":"CYT-125","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174546047060,"sku":"CYT-125","price":3510.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-fas-human-CYT-125.png?v=1776693735"},{"product_id":"cd95-human-his","title":"FAS Human, His","description":"\u003cp\u003esFas Receptor Human Recombinant, His Tag\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCD95, CD-95, Tumor necrosis factor receptor superfamily member 6, FASLG receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, CD95 antigen, FAS, APT1, FAS1, TNFRSF6, APO-1, FASTM, ALPS1A.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174546800724,"sku":"PRO-594","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174546833492,"sku":"PRO-594","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174546866260,"sku":"PRO-594","price":3000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cd95-human-his-PRO-594.png?v=1776680525"},{"product_id":"fas-tnfrsf6","title":"FAS Human, Sf9","description":"\u003cp\u003esFas Receptor Human Recombinant, Sf9\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eTumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, CD95, FAS, APT1, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174547750996,"sku":"CYT-1153","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174547783764,"sku":"CYT-1153","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174547816532,"sku":"CYT-1153","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-fas-tnfrsf6-CYT-1153.png?v=1776693739"},{"product_id":"faslg-human","title":"FASLG Human","description":"\u003cp\u003eFAS Ligand Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eTumor necrosis factor ligand superfamily member 6, Apoptosis antigen ligand, APTL, CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL, CD178, FASLG, APT1LG1, CD95L, TNFSF6, ALPS1B.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174548963412,"sku":"CYT-031","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174548996180,"sku":"CYT-031","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174549028948,"sku":"CYT-031","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-faslg-human-CYT-031.png?v=1776693744"},{"product_id":"faslg-human-hek","title":"FASLG Human, HEK","description":"\u003cp\u003eFAS Ligand Human Recombinant, HEK\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eFas ligand (TNF superfamily, member 6), APT1LG1, FASL, TNFSF6, CD178, tumor necrosis factor (ligand) superfamily member 6, Apoptosis antigen ligand, Fas antigen ligand, APTL, CD95-L.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174550044756,"sku":"CYT-051","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174550077524,"sku":"CYT-051","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174550110292,"sku":"CYT-051","price":3800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-faslg-human-hek-CYT-051.png?v=1776693748"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_83f11422-d793-4bec-9df3-d0c477a19f9d.png?v=1700646708","url":"https:\/\/prospecbio.com\/collections\/fas.oembed","provider":"prospecbio","version":"1.0","type":"link"}