{"title":"Exosome Component","description":"\u003ch2 class=\"highlited\"\u003e\u003cspan\u003eAbout EXOSC \/ Exosome Component:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eEXOSC Mechanism\u003c\/strong\u003e\u003cbr\u003eEXOSC genes encode a multiple protein intracellular complex and mediate the degradation of several types of RNA molecules. EXOSCs are found in archaea and eukaryotic cells and mainly mediate 3' to 5'mRNA degradation. A simpler complex known as the degradosome performs similar functions in bacteria.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eExosome Component Function\u003c\/strong\u003e\u003cbr\u003eThe proteins CD9, CD63, CD81, and CD82 (tetraspanins) participate in cell invasion, fusion, and penetration events. Also, heat shock EXOSC proteins HSP70 and HSP90 are integral to the stress response process and are involved in binding and presenting antigens. Additionally, TSG101 and Alix are MVB formation proteins that participate in the exosome release process. Annexins and Rab are also responsible for membrane fusion and transport. Finally, among these EXOSC proteins, certain types like ALinx, TSG101, and flotillin partake in exosome biogenesis. Others enriched in exosomes, like TSG101, CD81, CD63, and HSP70, are mainly used as exosomal marker proteins.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEXOSC Interactions\u003c\/strong\u003e\u003cbr\u003eExosome component 2 is known to interact with Exosome components 4 and 8. Exosome component 6 is also known to interact with Exosome component 1, Exosome component 7, and Exosome component 8. Finally, Exosome component 1 is known to interact with Exosome component 5, Exosome component 6, and Exosome component 7.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eExosome Component Structure\u003c\/strong\u003e\u003cbr\u003eThe RNA exosome includes ten conserved subunits that make a ring-like structure. This subunit core exosome contains a central, inert, six-subunit ring, a three-subunit cap, and an active ribonuclease associated with the base’s subunit ring. The eukaryotic RNA exosome has an eleventh RNA exonuclease sub-unit associated with the cap within the nucleus.\u003c\/p\u003e","products":[{"product_id":"exosc1-human","title":"EXOSC1 Human","description":"\u003cp\u003eExosome Component 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eExosome component 1, CGI-108, CSL4, Csl4p, hCsl4p, p13, RP11-452K12.9, SKI4, Ski4p, Exosome complex component CSL4, Exosome component 1, EXOSC1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174486016084,"sku":"PRO-1993","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174486048852,"sku":"PRO-1993","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174486081620,"sku":"PRO-1993","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-exosc1-human-PRO-1993.png?v=1776693465"},{"product_id":"exosc10-human","title":"EXOSC10  Human","description":"\u003cp\u003eExosome Component 10 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eExosome component 10, Polymyositis\/scleroderma autoantigen 2, Autoantigen PM\/Scl 2, Polymyositis\/scleroderma autoantigen 100 kDa, PM\/Scl-100, P100 polymyositis-scleroderma overlap syndrome-associated autoantigen, EXOSC10, PMSCL, PMSCL2, p2, p3, p4, RRP6, Rrp6p, PM-Scl.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174487031892,"sku":"PRO-444","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174487064660,"sku":"PRO-444","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174487097428,"sku":"PRO-444","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-exosc10-human-PRO-444.png?v=1776693469"},{"product_id":"exosc3-human","title":"EXOSC3 Human","description":"\u003cp\u003eExosome Component 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003ebA3J10.7, CGI-102, hRrp-40, p10, PCH1B, RP11-3J10.8, RRP40, Rrp40p, Exosome complex component RRP40, Exosome component 3, Ribosomal RNA-processing protein 40, EXOSC3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174487785556,"sku":"PRO-1981","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174487818324,"sku":"PRO-1981","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174487851092,"sku":"PRO-1981","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-exosc3-human-PRO-1981.png?v=1776693474"},{"product_id":"exosc5-human","title":"EXOSC5 Human","description":"\u003cp\u003eExosome Component 5 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eExosome component 5, Chronic myelogenous leukemia tumor antigen 28, Ribosomal RNA-processing protein 46, exosome complex exonuclease RRP46, RRP41B, hRrp46p, CML28, p12B.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174489391188,"sku":"PRO-1059","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43174489423956,"sku":"PRO-1059","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174489456724,"sku":"PRO-1059","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-exosc5-human-PRO-1059.png?v=1776693483"},{"product_id":"exosc7-human","title":"EXOSC7 Human","description":"\u003cp\u003eExosome Component 7 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eExosome Component 7, RRP42, Ribosomal RNA-Processing Protein 42, P8, Exosome Complex Exonuclease RRP42, Exosome Complex Component RRP42, KIAA0116, HRrp42p, EAP1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174490308692,"sku":"PRO-2144","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174490341460,"sku":"PRO-2144","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174490374228,"sku":"PRO-2144","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-exosc7-human-PRO-2144.png?v=1776693487"},{"product_id":"exosc8-human","title":"EXOSC8 Human","description":"\u003cp\u003eExosome Component 8 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eExosome Component 8, EXOSC8, OIP2, RRP43, CBP-Interacting Protein 3, Opa Interacting Protein 2, Opa-Interacting Protein 2, Ribosomal RNA-Processing Protein 43, OIP-2, p9, CIP3, EAP2, Rrp43p, bA421P11.3, Exosome Complex Component RRP43, Exosome Complex Exonuclease RRP43.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174491062356,"sku":"PRO-483","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174491095124,"sku":"PRO-483","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174491127892,"sku":"PRO-483","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-exosc8-human-PRO-483.png?v=1776693491"},{"product_id":"exosc9-human","title":"EXOSC9 Human","description":"\u003cp\u003eExosome Component 9 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eExosome component 9, PM\/Scl-75, PMSCL1, RRP45, Rrp45p, p5, p6, Polymyositis\/scleroderma autoantigen 1-75kDa, Autoantigen PM\/Scl 1, P75 polymyositis-scleroderma overlap syndrome-associated autoantigen, EC 3.1.13.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174491816020,"sku":"PRO-126","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174491848788,"sku":"PRO-126","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174491881556,"sku":"PRO-126","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-exosc9-human-PRO-126.png?v=1776693495"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_32daddf2-5131-40d8-b357-41932ef0bbed.png?v=1700646701","url":"https:\/\/prospecbio.com\/collections\/exosome-component.oembed","provider":"prospecbio","version":"1.0","type":"link"}