{"title":"EPH Receptor","description":"\u003ch2 class=\"highlited\"\u003e\u003cspan\u003eAbout EPH Receptor:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003eErythropoietin-producing hepatocellular carcinoma receptors, also known as Eph receptors, make up the largest subfamily of receptor tyrosine kinases. By 1987, research had shown that this group of receptors is linked with proliferative diseases such as cancer. Over the years, scientists have been seeking to gain more information on these relatively complex receptors.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEph Receptor Structure\u003c\/strong\u003e\u003cbr\u003eThe Eph receptors are the largest receptor tyrosine kinases (RTKs) subfamily because they consist of fourteen members classified under EphA and EphB subgroups. The various members are categorized based on their extracellular surface sequence homology and their preference to react to either the EphA or EphB ligands. However, it has been seen that promiscuous binding may occur; that is, EphA receptors can bind with EphB ligands, and EphB receptors can bind with EphA ligands. Through research such as the chimera experiment, scientists have discovered that promiscuous binding may create broader signaling functions for the Eph receptor.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEph Receptor Functions\u003c\/strong\u003e\u003cbr\u003eSince the Eph ligands are of a membrane-tethered nature, they are responsible for their Eph receptor’s ability to initiate intercellular signaling events upon cell-cell contact. These signaling events include but are not limited to axonal guidance, neural plasticity, angiogenesis, tissue patterning, and cell migration. Although it was initially believed that Eph receptors drive signaling using catalytic activities, research has shown that some receptors in the family have non-catalytic functions in the signaling process. For example, EphA10 and EphB4 have been found to have an absence in the amino acids needed to carry out a catalyze reaction. Such receptors are known as pseudokinases.\u003c\/p\u003e","products":[{"product_id":"epha2-human","title":"EPHA2 Human","description":"\u003cp\u003eEPH Receptor A2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eEPHA2, EPH Receptor A2, ECK, Tyrosine-Protein Kinase Receptor ECK, EC 2.7.10.1, CTRCT6, ARCC2, CTPP1, CTPA, Epithelial Cell Receptor Protein Tyrosine Kinase, Ephrin Type-A Receptor 2, Soluble EPHA2 Variant 1, Epithelial Cell Kinase, EC 2.7.10, EphA2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174424838228,"sku":"PRO-2032","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174424870996,"sku":"PRO-2032","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174424903764,"sku":"PRO-2032","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-epha2-human-PRO-2032.png?v=1776684003"},{"product_id":"epha2-human-sf9","title":"EPHA2 Human, sf9","description":"\u003cp\u003eEPH Receptor A2 Human Recombinant, sf9\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eEPHA2, ARCC2, CTPA, CTPP1, CTRCT6, ECK, EPHA2, sf9, EPH Receptor A2, sf9, Ephrin type-A receptor 2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174425657428,"sku":"PRO-2332","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174425690196,"sku":"PRO-2332","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174425722964,"sku":"PRO-2332","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-epha2-human-sf9-PRO-2332.png?v=1776684008"},{"product_id":"epha3-mouse","title":"EPHA3 Mouse","description":"\u003cp\u003eEPH Receptor A3 Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCek4, EK4, End3, ETK1, Hek, Hek4, Mek4, Tyro4, ephrin type-A receptor 3, ephrin type-A receptor 3 isoform1, receptor protein-tyrosine kinase, EPH-like kinase 4, tyrosine-protein kinase TYRO4, tyrosine-protein kinase receptor ETK1, Eph receptor A3, AW492086.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174427459668,"sku":"PRO-2817","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174427492436,"sku":"PRO-2817","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174427525204,"sku":"PRO-2817","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-epha3-mouse-PRO-2817.png?v=1776684022"},{"product_id":"epha4-mouse","title":"EPHA4 Mouse","description":"\u003cp\u003eEPH Receptor A4 Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eEphrin type-A receptor 4, Epha4, Tyrosine-protein kinase receptor MPK-3, Tyrosine-protein kinase receptor SEK-1, Sek, Sek1, EPHA4, EPH Receptor A4.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174428344404,"sku":"PRO-2339","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174428377172,"sku":"PRO-2339","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174428409940,"sku":"PRO-2339","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-epha4-mouse-PRO-2339.png?v=1776684028"},{"product_id":"ephb1-human","title":"EPHB1 Human","description":"\u003cp\u003eEPH Receptor B1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eEPHB-1, Ephrin type-B receptor 1, Eph Receptor B1, ELK, EPH tyrosine kinase 2, EPH-like kinase 6, EK6, hEK6, HEK6, Neuronally-expressed EPH-related tyrosine kinase, NET, NETHek6, Tyrosine-protein kinase receptor EPH-2, EPHT2, soluble EPHB1 variant 1\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174429098068,"sku":"PRO-2728","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174429130836,"sku":"PRO-2728","price":145.0,"currency_code":"USD","in_stock":true},{"title":"0.1mg","offer_id":43174429163604,"sku":"PRO-2728","price":1000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-ephb1-human-PRO-2728.png?v=1776684035"},{"product_id":"ephb2-human","title":"EPHB2 Human","description":"\u003cp\u003eEPH Receptor B2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eEPHB2, CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5, Developmentally-regulated\nEph-related tyrosine kinase, ELK-related tyrosine kinase, EPH tyrosine kinase\n3, EPH-like kinase 5, hEK5, Renal carcinoma antigen NY-REN-47, Tyrosine-protein\nkinase TYRO5, Tyrosine-protein kinase receptor EPH-3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174430113876,"sku":"PRO-2379","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174430146644,"sku":"PRO-2379","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174430179412,"sku":"PRO-2379","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-ephb2-human-PRO-2379.png?v=1776684042"},{"product_id":"ephb4-mouse","title":"EPHB4 Mouse","description":"\u003cp\u003eEPH Receptor B4 Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eEphrin type-B receptor 4 (EC:2.7.10.1), Developmental kinase 2, mDK-2, Hepatoma transmembrane kinase, Tyrosine kinase MYK-1, Ephb4, Htk, Mdk2, Myk1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174431948884,"sku":"PRO-2344","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174431981652,"sku":"PRO-2344","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174432014420,"sku":"PRO-2344","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-ephb4-mouse-PRO-2344.png?v=1776684054"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_166016bd-a4ca-40ad-ba6e-814566ca63c4.png?v=1700646685","url":"https:\/\/prospecbio.com\/collections\/eph-receptor.oembed","provider":"prospecbio","version":"1.0","type":"link"}