{"title":"Eotaxin (CCL11,24,26)","description":"\u003ch3 class=\"highlited\"\u003e\u003cspan\u003eAbout Eotaxin:\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003eEotaxin refers to a subfamily of proteins that are categorized as being eosinophil chemotactic. There are three members of the eotaxin family in humans; eotaxin-1, eotaxin-2, and eotaxin-3. This family is defined as a CC Chemokine family because two of its cysteines are next to their amino terminus.\u003cbr\u003eEotaxin-1 is encoded by the CC11 gene, and you will find it on chromosome 17. Eotaxin-2 is encoded by the CCL24 gene and will be found on chromosome 7. Finally, eotaxin-3 is encoded by the CCL26 gene and is also found on chromosome 4 in humans.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStructure\u003c\/strong\u003e\u003cbr\u003eThe structural makeup of eotaxin is easily characterized thanks to its four cysteines. As already mentioned, two of these are found adjacent to the amino terminus. The eotaxin found in humans is said to be an 8.4kDA, 74 aa residue polypeptide.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism \u0026amp; Interactions\u003c\/strong\u003e\u003cbr\u003eAll three members of the eotaxin family are produced by numerous cells throughout the human body. Eotaxin-1 is known for carefully recruiting eosinophils (these are a type of white blood cells) by forcing them to move. It binds to a chemokine receptor - which is a G-protein-linked receptor. This member of the eotaxin family is said to be particularly selective about which chemokine receptors it binds to. Technically speaking, it has the ability to bind to CCR2, CCR3 and CCR5. Nevertheless, it mainly only binds to CCR3. There have been many instances where eotaxin-1 refuses to bind with certain types of white blood cell that does not exhibit the chemokine receptor CCR3.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEotaxin-2\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ealso interacts with the chemokine receptor CCR3. This is the only receptor it interacts with, but it also helps produce the chemotaxis effect in eosinophils. Furthermore, unlike eotaxin-1, this eotaxin is known to induce major chemotaxis in T lymphocytes, and even a slight bit in neutrophils.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEotaxin-3\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ecompletes the group of eotaxins that has an affinity to bind with chemokine receptor CCR3. It is produced throughout the body by several tissues in major organs such as the heart, ovary, and lung. Furthermore, many endothelial cells express eotaxin-3 if they have been properly stimulated. Eotaxin-3 is considered to be extremely chemotactic for both basophils and eosinophils - this means it induces chemotaxis in both.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunction\u003c\/strong\u003e\u003cbr\u003eThe primary function of eotaxin is to work with eosinophils. It can help induce chemotaxis in these white blood cells, which essentially means it gets them to move towards certain areas of the body. In essence, this helps deal with inflammation by swarming the inflamed area with white blood cells to help fight it off. Eotaxins normally function in relation to allergic responses, but there have been various studies involving test subjects with high eotaxin levels.\u003cbr\u003eMost notably, it’s found that patients with asthma tend to have abnormally elevated levels of eotaxin-2 in their blood. It’s considered this is due to the fact that patients with asthma will usually have an allergic reaction to something or suffer from inflammation of some kind. Therefore, the eotaxin family kicks into action in an attempt to recruit eosinophils by forcing chemotaxis in these cells.\u003c\/p\u003e","products":[{"product_id":"ccl24-human","title":"Eotaxin 2 Human","description":"\u003cp\u003eEotaxin-2 Human Recombinant (CCL24)\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eC-C motif chemokine 24, Small-inducible cytokine A24, Myeloid progenitor inhibitory factor 2, CK-beta-6, Eosinophil chemotactic protein 2, Eotaxin-2, CCL24, Ckb-6, MPIF2, MPIF-2, SCYA24, Eotaxin2, 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CCL-24.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174412058708,"sku":"CHM-282","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174412091476,"sku":"CHM-282","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174412124244,"sku":"CHM-282","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-eotaxin-2-rat-CHM-282.png?v=1776683915"},{"product_id":"eotaxin-3-human","title":"Eotaxin 3 Human","description":"\u003cp\u003eEotaxin-3 Human Recombinant (CCL26)\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eC-C motif chemokine 26, Small-inducible cytokine A26, Eotaxin-3, Macrophage inflammatory protein 4-alpha, MIP-4-alpha, Thymic stroma chemokine-1, TSC-1, CC chemokine IMAC, CCL26, SCYA26, IMAC, MIP-4a, MGC126714, MIP-4alpha.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43174413008980,"sku":"CHM-362","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174413041748,"sku":"CHM-362","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174413074516,"sku":"CHM-362","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-eotaxin-3-human-CHM-362.png?v=1776683920"},{"product_id":"eotaxin-human","title":"Eotaxin Human","description":"\u003cp\u003eEotaxin Human Recombinant (CCL11)\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSmall inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine (C-C motif) ligand 11, SCYA11, MGC22554.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174413992020,"sku":"CHM-256","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174414024788,"sku":"CHM-256","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174414057556,"sku":"CHM-256","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-eotaxin-human-CHM-256.png?v=1776683926"},{"product_id":"eotaxin-human-his","title":"Eotaxin Human, His","description":"\u003cp\u003eEotaxin Human Recombinant (CCL11), His Tag\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSmall inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine (C-C motif) ligand 11, SCYA11, MGC22554.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174414843988,"sku":"CHM-344","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174414876756,"sku":"CHM-344","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174414909524,"sku":"CHM-344","price":2000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-eotaxin-human-his-CHM-344.png?v=1776683934"},{"product_id":"eotaxin-mouse","title":"Eotaxin Mouse","description":"\u003cp\u003eEotaxin Mouse Recombinant (CCL11)\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSmall inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine (C-C motif) ligand 11, SCYA11.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174415663188,"sku":"CHM-308","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174415695956,"sku":"CHM-308","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174415728724,"sku":"CHM-308","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-eotaxin-mouse-CHM-308.png?v=1776683938"},{"product_id":"eotaxin-rat","title":"Eotaxin Rat","description":"\u003cp\u003eEotaxin Rat Recombinant (CCL11)\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSmall inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine (C-C motif) ligand 11, SCYA11.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174416580692,"sku":"CHM-260","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174416613460,"sku":"CHM-260","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174416646228,"sku":"CHM-260","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-eotaxin-rat-CHM-260.png?v=1776683944"},{"product_id":"eotaxin-rhesus-macaque","title":"Eotaxin Rhesus Macaque","description":"\u003cp\u003eEotaxin Rhesus Macaque Recombinant (CCL11)\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eSmall inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine (C-C motif) ligand 11, SCYA11, 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