{"title":"Elongator Acetyltransferase Complex","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout ELP \/ Elongator Acetyltransferase Complex:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eElongator Acetyltransferase Complex, also known as ELP, associates with RNA polymerase II during transcriptional elongation. It’s a 6-subunit histone acetyltransferase that’s linked with ELP2, which functions as a core subunit of the complex.\u003cbr data-mce-fragment=\"1\"\u003eThe ELP2 was identified in 2002 by Hawkes et al., who discovered it through the mass spectrometric analysis method of looking at proteins that were purified with the elongator complex.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eELP Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eStructurally, it has eight putative WD40 repeats and a C-terminal region. Homologically speaking, it connects with the signature-2 motif of RCC1. The mass of ELP2 is 95 kD by SDS-PAGE.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eElongator Acetyltransferase Complex Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe elongator complex will copurify with ELP2 from HeLa cells. There are two forms of elongator complex; the holo-elongator and a 3-subunit core form. The first has a histone acetyltransferase that is active against histones H3 and H4. The second does not have histone acetyltransferase activity, even though it contains ELP3, a catalytic subunit. ELP2 and IKAP are also present in the core elongator complex, while ELP4, ELP5, and ELP6 were found in the active holo-elongator complex.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eELP Sequence\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe ELP2 gene is mapped to 18q12.2, a chromosome. This is based on an alignment of the sequence of ELP2 with the genomic sequence. Looking at it from a lens of molecular genetics, we should look at it through a study of homozygosity mapping, which was conducted on 136 consanguineous families with segregating syndromic or nonsyndromic forms of autosomal recessive intellectual disability. A homozygous missense mutation of the ELP2 gene was identified in two families. The mutations segregated with the disorder in the family.\u003c\/p\u003e","products":[{"product_id":"elp4-human","title":"ELP4 Human","description":"\u003cp\u003eElongator Acetyltransferase Complex Subunit 4 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eElongator complex protein 4, ELP4, Elongator Acetyltransferase Complex Subunit 4, hELP4, PAX6 neighbor gene protein, C11orf19, PAXNEB, dJ68P15A.1, PAX6NEB.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174369427540,"sku":"PRO-2102","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174369460308,"sku":"PRO-2102","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174369493076,"sku":"PRO-2102","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-elp4-human-PRO-2102.png?v=1776683634"},{"product_id":"elp5-human","title":"ELP5 Human","description":"\u003cp\u003eElongator Acetyltransferase Complex Subunit 5 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eC17orf81, DERP6, HSPC002, MST071, MSTP071, Dermal papilla-derived protein 6, S-phase 2 protein, ELP5.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174370246740,"sku":"PRO-1660","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174370279508,"sku":"PRO-1660","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174370312276,"sku":"PRO-1660","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-elp5-human-PRO-1660.png?v=1776683640"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_63e968d1-4b8d-443f-abb9-be6353e22876.png?v=1700646673","url":"https:\/\/prospecbio.com\/collections\/elongator-acetyltransferase-complex.oembed","provider":"prospecbio","version":"1.0","type":"link"}