{"title":"Ectodysplasin","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout EDA \/ Ectodysplasin:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eEDA Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eEctodysplasin Protein (EDA) is a type II transmembrane protein, including a C-Terminal tumor necrosis factor (TNF). It also possesses a furin site and a collagen-like sequence in the link between the transmembrane helix and the TNF domain. EDA-A1 and EDA-A2 are the common isoforms; EDA-A1 binds with the Ectodysplasin-A Receptor (EDAR), while EDA-A2 binds with X-linked Ectodysplasin-A Receptor (XEDAR).\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eEctodysplasin Interaction\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eEDA interacts with a protein known as the Ectodysplasin-A Receptor (EDAR), with EDA attaching to it like a key in a lock. Their connection activates a series of chemical signals that impact cell activities such as cell growth, maturation, and division. This signaling pathway regulates the teeth, hair follicles, sweat glands, and several ectodermal formations.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eEDA Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eEDA is created from the EDA gene’s instruction and plays a significant role in development before birth. It’s part of a signaling pathway and facilitates the interaction between two embryonic cell layers called the ectoderm and mesoderm. These layers are the foundation of the body's tissues and organs in the embryonic stage. They also play a pivotal role in skin, hair, teeth, sweat gland, nail development, and other ectodermal structures.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eEDA and EDAR expression\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eEDA and EDAR express themselves in partially overlapping tissues in the skin and can interact with each other. During 20 weeks of gestation, EDA is expressed in the epidermis. EDAR, on the other hand, is limited to the periderm and is associated with the formation of epidermal appendages and epithelial thickening.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eConsequences of EDA gene mutation\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eEDA gene mutations cause ectodermal dysplasia, which results in the abnormal formation of the hair, skin, teeth, nails, and sweat glands. It causes a reduced sweating ability, missing teeth, malformed teeth, and scanty scalp and body hair.\u003c\/p\u003e","products":[{"product_id":"eda2r-human","title":"EDA2R Human","description":"\u003cp\u003eEctodysplasin A2 Receptor Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eEctodysplasin A2 Receptor, XEDAR, TNFRSF27, EDA-A2 Receptor, X-Linked Ectodysplasin-A2 Receptor, EDAA2R, EDA-A2R, Tumor Necrosis Factor Receptor Superfamily Member 27, Tumor Necrosis Factor Receptor Superfamily Member XEDAR, EDAR2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174285869140,"sku":"PRO-1744","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174285901908,"sku":"PRO-1744","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174285934676,"sku":"PRO-1744","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-eda2r-human-PRO-1744.png?v=1776683162"},{"product_id":"eda2r-sf9","title":"EDA2R Human, Sf9","description":"\u003cp\u003eEctodysplasin A2 Receptor Human Recombinant, Sf9\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eTumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, Ectodysplasin A2 Receptor, X-Linked Ectodysplasin-A2 Receptor, EDA-A2 Receptor, TNFRSF27, XEDAR, Tumor Necrosis Factor Receptor Superfamily Member XEDAR, Tumor Necrosis Factor Receptor Superfamily Member 27, Ectodysplasin A2 Isoform Receptor, EDA-A2R, EDAA2R.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174286983252,"sku":"PRO-2399","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174287016020,"sku":"PRO-2399","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174287048788,"sku":"PRO-2399","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-eda2r-sf9-PRO-2399.png?v=1776683167"},{"product_id":"edar-human","title":"EDAR Human","description":"\u003cp\u003eEctodysplasin A Receptor Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eEctodysplasin A Receptor, DL, Ectodysplasin 1, Anhidrotic\nReceptor, Anhidrotic Ectodysplasin Receptor 1, Ectodermal Dysplasia Receptor,\nEctodysplasin-A Receptor, Downless Homolog, EDA-A1 Receptor, ECTD10A, ECTD10B, EDA3,\nHRM1, ED3, Tumor Necrosis Factor Receptor Superfamily Member EDAR, Downless,\nMouse, Homolog Of, EDA-A1R, EDA1R, ED1R, ED5, Tumor necrosis factor receptor\nsuperfamily member EDAR.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174289178708,"sku":"PRO-2092","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174289211476,"sku":"PRO-2092","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174289244244,"sku":"PRO-2092","price":3600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-edar-human-PRO-2092.png?v=1776683177"},{"product_id":"edar-protein","title":"EDAR Human, Sf9","description":"\u003cp\u003eEctodysplasin A Receptor Human Recombinant, Sf9\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eEctodysplasin A Receptor, Ectodysplasin 1, Anhidrotic Receptor, Anhidrotic Ectodysplasin Receptor 1, Ectodermal Dysplasia Receptor, Downless Homolog, EDA-A1 Receptor, DL, Tumor Necrosis Factor Receptor Superfamily Member EDAR, Downless, Mouse, Homolog Of, Ectodysplasin-A Receptor, ECTD10A, ECTD10B, EDA-A1R, EDA1R, ED1R, EDA3, HRM1, ED5, ED3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174289768532,"sku":"PRO-2510","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174289801300,"sku":"PRO-2510","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174289834068,"sku":"PRO-2510","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-edar-protein-PRO-2510.png?v=1776683183"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_9306bec8-68c2-4358-bd38-ffd170e2e426.png?v=1700646663","url":"https:\/\/prospecbio.com\/collections\/ectodysplasin.oembed","provider":"prospecbio","version":"1.0","type":"link"}