{"title":"DNA-Damage Protein","description":"\u003ch2 class=\"highlited\"\u003e\u003cspan\u003eAbout DNA-Damage Protein:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003eDNA damage proteins are collectively known as the DNA damage response, otherwise shortened to DDR. They are sophisticated cellular networks that continually monitor genome integrity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDNA-Damage Protein Mechanism\u003c\/strong\u003e\u003cbr\u003eOne of the most common features of DNA damage response proteins is how they mobilize as a response to genotoxic stress. A number of complementary methodologies have developed that have supplied us with key insights with regard to the spatiotemporal dynamics of DDR protein assembly and disassembly at DNA strand break sites within eukaryotic cells.\u003cbr\u003eA number of important advancements have also been made with regard to our comprehension of the molecular mechanisms that underpin these events. Significant advances have also been made when it comes to our comprehension of the molecular mechanisms that underlie these events, as post-translation modifications of DDR factors have been shown to play a critical role when it comes to the controlling of foci formation in response to DNA-damaging agents.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDNA-Damage Protein Function\u003c\/strong\u003e\u003cbr\u003eDNA DSBs represent the most deleterious type of DNA damage, as they will not leave a complementary strand intact that could be utilized as a DNA repair template. If this is not repaired, they can end up resulting in translocations and chromosome breaks that have been linked with the likes of cancer predisposition, sterility, radiosensitivity, immunodeficiency, neurodegeneration, and developmental defects.\u003c\/p\u003e","products":[{"product_id":"ddit3-human","title":"DDIT3 Human","description":"\u003cp\u003eDNA Damage Inducible Transcript 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eDNA damage-inducible transcript 3, DDIT-3, Growth arrest and DNA-damage-inducible protein GADD153, C\/EBP-homologous protein, CHOP, DDIT3, GADD153, CEBPZ, CHOP10, MGC4154.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174099058772,"sku":"PRO-638","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174099091540,"sku":"PRO-638","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174099124308,"sku":"PRO-638","price":3600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-ddit3-human-PRO-638.png?v=1776441716"},{"product_id":"ddit4-human","title":"DDIT4 Human","description":"\u003cp\u003eDNA Damage Inducible Transcript 4 Recombinant Human\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eDNA-damage-inducible transcript 4, RTP801, REDD-1, Dig2, FLJ20500, Protein regulated in development and DNA damage response 1, HIF-1 responsive protein RTP801, RP11-442H21.1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174100140116,"sku":"PRO-094","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174100172884,"sku":"PRO-094","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174100205652,"sku":"PRO-094","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-ddit4-human-PRO-094.png?v=1776441721"},{"product_id":"pdrg1-human","title":"PDRG1 Human","description":"\u003cp\u003ep53 and DNA-Damage Regulated 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003ep53 and DNA damage-regulated protein 1, PDRG1, C20orf126, PDRG.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174581829716,"sku":"PRO-007","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174581862484,"sku":"PRO-007","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174581895252,"sku":"PRO-007","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-pdrg1-human-PRO-007.png?v=1776705248"},{"product_id":"gadd45a-human","title":"GADD45A Human","description":"\u003cp\u003eGrowth Arrest and DNA-Damage-Inducible Alpha Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eGrowth arrest and DNA damage-inducible protein GADD45 alpha, DNA damage-inducible transcript 1 protein, DDIT-1, GADD45A, DDIT1, GADD45.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174783942740,"sku":"PRO-783","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43174783975508,"sku":"PRO-783","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174784008276,"sku":"PRO-783","price":2250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gadd45a-human-PRO-783.png?v=1776694807"},{"product_id":"gadd45b-human","title":"GADD45B Human","description":"\u003cp\u003eGrowth Arrest and DNA-Damage-Inducible Beta Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eMYD118, GADD45BETA, GADD45B, Growth arrest and DNA-damage-inducible protein GADD45 beta, Myeloid differentiation primary response protein MyD118, Negative growth regulatory protein MyD118, DKFZp566B133.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43174784794708,"sku":"PRO-563","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174784827476,"sku":"PRO-563","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174784860244,"sku":"PRO-563","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gadd45b-human-PRO-563.png?v=1776694811"},{"product_id":"gadd45g-human","title":"GADD45G Human","description":"\u003cp\u003eGrowth Arrest and DNA-Damage-Inducible Gamma Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eDDIT2, GADD45gamma, GADD45G, Growth arrest and DNA-damage-inducible protein GADD45 gamma, Cytokine-responsive protein CR6, DNA-damage-inducible transcript 2, DDIT-2, CR6, GRP17.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43174785646676,"sku":"PRO-570","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174785679444,"sku":"PRO-570","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174785712212,"sku":"PRO-570","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gadd45g-human-PRO-570.png?v=1776694815"},{"product_id":"gadd45gip1-human","title":"GADD45GIP1 Human","description":"\u003cp\u003eGrowth Arrest and DNA-Damage-Inducible Gamma Interacting Protein 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eGrowth arrest and DNA-damage-inducible gamma interacting protein 1, PRG6, CRIF1, PLINP-1, KBBP2, Plinp1, Papillomavirus L2-interacting nuclear protein 1, CKII beta-associating protein, CR6-interacting factor 1, p53-responsive gene 6 protein, CKII beta binding protein 2, growth arrest and DNA damage-inducible proteins-interacting protein 1, papillomavirus L2 interacting nuclear protein 1, PLINP1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174786564180,"sku":"PRO-972","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174786596948,"sku":"PRO-972","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174786629716,"sku":"PRO-972","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-gadd45gip1-human-PRO-972.png?v=1776694820"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_b3e23ba6-a593-44e1-b2dd-9910da5d8304.png?v=1700646639","url":"https:\/\/prospecbio.com\/collections\/dna-damage-protein.oembed","provider":"prospecbio","version":"1.0","type":"link"}