{"title":"CUE Domain Containing","description":"\u003cmain class=\"main container-fluid\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"row\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"tab-content col-xs-12 col-sm-10 col-lg-10\" data-mce-fragment=\"1\"\u003e\n\u003cdiv class=\"row\" data-mce-fragment=\"1\"\u003e\n\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout CUEDC \/ CUE Domain Containing:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eCUEDC Mechanism\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe CUE domain containing (CUEDC) protein acts on both the surface and underlying structures, and acts as a protein coding gene, entirely encoded by the CUEDC1 gene. This ensures that the protein molecule is not a monomer, and acts on a molecular level only binding ubiquitin, and often acts in a chain.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eCUE Domain Containing Interactions\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe CUEDC acts as a binder, and has its own domain. Within this domain, it binds in terms of both mono and polyubiquitin, and there are even some proteins that are ubiquitinylated in these binding terms alone, being entirely dependent on CUEDC itself. CUEDC acts on two proteins in the IL-1 signal transduction pathway, as well as human Tollip proteins, and in TAB2.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eCUEDC Function\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eResearch into the CUE Domain Containing, or CUEDC protein initially described a relation between the yeast Cue1 protein and human Tollip proteins. The region between the two is 40 amino acids long, and is found in a variety of proteins with differing functions. This includes the endoplasmic reticulum, in which the CUEDC protein helps to regulate misfolded proteins.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eCUE Domain Containing Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eMade up of a three-helix bundle model, and in terms of its structure, is related to the UBA domain, which is shown through the existence of the domain structure of its own. Often containing a hydrophobic patch, the structure of the CUEDC can also exist entirely as a dimer, being domain swapped in nature. When existing in this matter, it acts as a further binding partner for ubiquitin in a higher affinity.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/main\u003e","products":[{"product_id":"cuedc1-human","title":"CUEDC1 Human","description":"\u003cp\u003eCUE Domain Containing 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCUE Domain Containing 1, CUE Domain-Containing Protein 1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174022447188,"sku":"PRO-1822","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174022479956,"sku":"PRO-1822","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174022512724,"sku":"PRO-1822","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cuedc1-human-PRO-1822.png?v=1776682387"},{"product_id":"cuedc2-human","title":"CUEDC2 Human","description":"\u003cp\u003eCUE Domain Containing 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCUE domain-containing protein 2, CUEDC2, C10orf66, HOYS6, bA18I14.5.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174023168084,"sku":"PRO-1680","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174023200852,"sku":"PRO-1680","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174023233620,"sku":"PRO-1680","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cuedc2-human-PRO-1680.png?v=1776682391"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_10c5a5c7-7b41-44e1-a222-35b26543dfaf.png?v=1700646618","url":"https:\/\/prospecbio.com\/collections\/cue-domain-containing.oembed","provider":"prospecbio","version":"1.0","type":"link"}