{"title":"COP9 Signalosome","description":"\u003ch2 class=\"highlited\"\u003e\u003cspan\u003eAbout COP9 Signalosome:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003eSince its discovery, the COP9 Signalosome has been the subject of intense research in recent years. The mechanism, structures, and interactions are being discovered and refined all the time, with researchers only just scratching the surface of this fascinating protein.\u003cbr\u003eCOP9 Signalsome (Constitutive photomorphogenesis CSN) was first identified in various species of plants. Having been initially determined to be a negative regulator of Constitutive Photomorphogensiss (COP) within the plant, it was later found outside plant-based organisms.\u003cbr\u003eOn a further study by researchers, COP9 signalosome was then found to be present not only in plants but in humans and in all eukaryotic organisms. Eukaryotic organisms are those defined as containing cells with a nucleus enclosed inside a nuclear envelope.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCOP9 Signalsome Structure\u003c\/strong\u003e\u003cbr\u003eThe COPS is a protein complex with marked isopeptidase activity. COPS found in humans is made up of 8 subunits: CSN1, CSN2, CSN3, CSN4, CSN5, CSN6, CSN7 (COPS7A and COPS7B), CSN8.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCOP9 Signalsome Function\u003c\/strong\u003e\u003cbr\u003eCOPS was found to have a similar structure to sub-complex 26S proteasome and CSN, after being initially being thought of as a photomorphogenesis depressor in Arabidopsis, has been identified as an important factor in the cellular and developmental processes of eukaryotic organisms.\u003cbr\u003eRecent studies into the function of COPS have shown that it is critical in sustaining SCF activity in this and cullin-based ubiquitin ligases. It is also able to bind denedyllated cullin-RING complex yet retains them, making it a sole deactivator or CRLs.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCOP9 Signalsome Applications\u003c\/strong\u003e\u003cbr\u003eCOPS is currently being for drug applications, with early trials indicating that the death of cancer cells could be achieved by inhibiting COPS.\u003c\/p\u003e","products":[{"product_id":"cops6-human","title":"COPS6 Human","description":"\u003cp\u003eCOP9 Constitutive Photomorphogenic 6 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCSN6, MOV34-34KD, COP9 signalosome complex subunit 6, JAB1-containing signalosome subunit 6, MOV34 homolog, Vpr-interacting protein, hVIP, COPS6.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175145177172,"sku":"PRO-1650","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175145209940,"sku":"PRO-1650","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175145242708,"sku":"PRO-1650","price":3600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cops6-human-PRO-1650.png?v=1776681933"},{"product_id":"cops7a-human","title":"COPS7A Human","description":"\u003cp\u003eCOP9 Signalosome Subunit 7A Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCOP9 Signalosome Subunit 7A, COPS7A, Dermal Papilla-Derived Protein 10, CSN7A, SGN7a, JAB1-Containing Signalosome Subunit 7a, COP9 Complex Subunit 7a, COP9 Constitutive Photomorphogenic Homolog Subunit 7A, COP9 Signalosome Complex Subunit 7a, DERP10, Signalosome Subunit 7a.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175146291284,"sku":"PRO-1947","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175146324052,"sku":"PRO-1947","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175146356820,"sku":"PRO-1947","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cops7a-human-PRO-1947.png?v=1776681939"},{"product_id":"cops8-human","title":"COPS8 Human","description":"\u003cp\u003eCOP9 Constitutive Photomorphogenic 8 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCOP9 signalosome complex subunit 8, SGN8, Signalosome subunit 8, COP9 homolog, hCOP9, JAB1-containing signalosome subunit 8, COPS8, CSN8, COP9.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43175147405396,"sku":"PRO-983","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43175147438164,"sku":"PRO-983","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43175147470932,"sku":"PRO-983","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cops8-human-PRO-983.png?v=1776681944"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_2c89388d-0ae1-4cea-94aa-e618820bd660.png?v=1700646591","url":"https:\/\/prospecbio.com\/collections\/cop9-signalosome.oembed","provider":"prospecbio","version":"1.0","type":"link"}