{"title":"Cofilin","description":"\u003ch2 class=\"highlited\"\u003e\u003cspan\u003eAbout CFL \/ Cofilin:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003ecofilin plays a role in the depolymerization of actin microfilaments.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCFL Structure\u003c\/strong\u003e\u003cbr\u003eCofilin or CFL as it is also known is a protein similar to destrin that is part of the ADF\/cofilin family of small ADP-binding proteins. There are two types of cofilin CFL1, coding for cofilin 1 (non-muscle, or n-cofilin) and CFL2, coding for cofilin 2 (found in muscle: m-cofilin).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCofilin Function\u003c\/strong\u003e\u003cbr\u003eCofilin is associated with several functions including cell transcription regulation, cell motility, and muscle contraction. Cofilin is important to these processes because it prompts dynamic instability of the actin microfilaments. This is because cofilin is an actin-binding protein associated with rapid depolymerization of actin microfilaments.\u003cbr\u003eIndeed, cofilin is responsible for the depolymerization at the minus end of filaments, thus preventing their reassembly.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCFL Mechanism\u003c\/strong\u003e\u003cbr\u003eCofilin prevents filament reassembly in two ways. The first is by depolymerizing old actin filaments. While the second is by creating new ends for polymerization. In essence, what this process does is cause the molecule to twist. This, then adds strain to the molecule and therefore destabilizes it.\u003cbr\u003eThis twisting process is then enhanced as the actin-depolymerizing factor then binds to the destabilized F-actin. This is a process that is made possible because the actin-depolymerizing factor can insert the central helix into the cleft between the first and third actin subunits.\u003cbr\u003eThis change in the F-actin causes the molecule to twist further and become even more destabilized. Therefore, effectively severing the bond between the actins and effectively depolymerizing the filament.\u003c\/p\u003e","products":[{"product_id":"cfl1-human","title":"CFL1 Human","description":"\u003cp\u003eCofilin-1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCFL-1, CFL1, Cofilin1, Cofilin-1, Cofilin, non-muscle isoform, 18 kDa phosphoprotein, p18.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174964789332,"sku":"PRO-591","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174964822100,"sku":"PRO-591","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174964854868,"sku":"PRO-591","price":3600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cfl1-human-PRO-591.png?v=1776680957"},{"product_id":"cfl2-human","title":"CFL2 Human","description":"\u003cp\u003eCofilin-2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCofilin-2, Cofilin- muscle isoform, CFL2, NEM7.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174965608532,"sku":"PRO-912","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174965641300,"sku":"PRO-912","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174965674068,"sku":"PRO-912","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cfl2-human-PRO-912.png?v=1776680961"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_06a164f6-39ae-49ca-80de-684417d97d28.png?v=1700646557","url":"https:\/\/prospecbio.com\/collections\/cofilin.oembed","provider":"prospecbio","version":"1.0","type":"link"}