{"title":"Centromere Protein","description":"\u003ch2 class=\"highlited\"\u003e\u003cspan\u003eAbout CENP \/ Centromere Protein:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003eCentromere proteins are components of the nucleosome distal complex, required by centromeres to assemble kinetochore proteins, chromosome segregation and mitotic progressions. Throughout its history and discovery, centromere protein has had many different names, including Cse4p in yeast, Cid in fruit flies, and Cnplp in fission yeast.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCENP Function\u003c\/strong\u003e\u003cbr\u003eCentromere protein A (CENP-A) is a centromeric variant of the regular histone H3, found mainly in the centromeric region during periods of replication. It plays a vital role in the regulation of centromere formation, genome stability and the constriction of the kinetochore. De novo centromere assembly is dependent on RNA interference and heterochromatic pathways in yeast.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCentromere Protein Structure\u003c\/strong\u003e\u003cbr\u003eThis histone variant is different from the H2A histone because it contains a macro domain at the C-terminal end. The protein is only found in vertebrates and is 60 percent similar to its canonical counterpart.\u003cbr\u003eCENP-A is a histone variant, but essential for survival. The fold domain of the protein appears to be evolutionarily conserved, thanks to the high percentage similarity to the H3 histone. In terms of evolution, it appears to be one of the fastest-evolving histones, similar to H3.3.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCENP Mechanism\u003c\/strong\u003e\u003cbr\u003eCENP-A is interesting from a scientific perspective because of its ability to create split nucleosomes in fruit flies. Being able to do this is something that has challenged the chromatin field, but it now appears to be possible.\u003cbr\u003eIt has also been shown that recombinant CENP-A and the complementary core histone counterpart may be able to reconstitute full nucleosomes in vitro, representing a significant methodological and experimental breakthrough.\u003c\/p\u003e","products":[{"product_id":"cenpa-human","title":"CENPA Human","description":"\u003cp\u003eCentromere Protein A Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eHistone H3-like centromeric protein A, Centromere protein A, CENP-A, Centromere autoantigen A, CENPA.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174941360212,"sku":"PRO-389","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174941392980,"sku":"PRO-389","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174941425748,"sku":"PRO-389","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cenpa-human-PRO-389.png?v=1776680829"},{"product_id":"cenpb-human","title":"CENPB Human","description":"\u003cp\u003eCentromere Protein B Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eMajor centromere autoantigen B, Centromere protein B, CENP-B, CENPB.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174942310484,"sku":"PRO-390","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174942343252,"sku":"PRO-390","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174942376020,"sku":"PRO-390","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cenpb-human-PRO-390.png?v=1776680835"},{"product_id":"cenph-human","title":"CENPH Human","description":"\u003cp\u003eCentromere Protein-H Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCentromere protein H, Interphase centromere complex protein 35, CENP-H, NNF1, PMF1, ICEN35, Kinetochore protein CENP-H.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174943359060,"sku":"PRO-966","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174943391828,"sku":"PRO-966","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174943424596,"sku":"PRO-966","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cenph-human-PRO-966.png?v=1776680839"},{"product_id":"cenpm-human","title":"CENPM Human","description":"\u003cp\u003eCentromere Protein-M Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCentromere Protein M, Interphase Centromere Complex Protein 39, Chromosome 22 Open Reading Frame 18, Proliferation Associated Nuclear Element 1, bK250D10.2, CENP-M, ICEN39, C22orf18, PANE1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174943948884,"sku":"PRO-1626","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174943981652,"sku":"PRO-1626","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174944014420,"sku":"PRO-1626","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cenpm-human-PRO-1626.png?v=1776680845"},{"product_id":"cenpp-human","title":"CENPP Human","description":"\u003cp\u003eCentromere Protein-P Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCentromere protein P, CENP-P, CENPP.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174944833620,"sku":"PRO-1784","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174944866388,"sku":"PRO-1784","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174944899156,"sku":"PRO-1784","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cenpp-human-PRO-1784.png?v=1776680850"},{"product_id":"cenpq-human","title":"CENPQ Human","description":"\u003cp\u003eCentromere Protein-Q Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCentromere protein Q, CENPQ, CENP-Q, C6orf139, Centromere Protein-Q.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174945620052,"sku":"PRO-1815","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174945652820,"sku":"PRO-1815","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174945685588,"sku":"PRO-1815","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cenpq-human-PRO-1815.png?v=1776680855"},{"product_id":"cenpu-human","title":"CENPU Human","description":"\u003cp\u003eCentromere Protein-U Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCentromere Protein U, MLF1IP, Polo-Box-Interacting\nProtein 1, MLF1 Interacting Protein, Centromere Protein Of 50 KDa, Interphase\nCentromere Complex Protein 24, KLIP1, PBIP1, KSHV Latent Nuclear\nAntigen-Interacting Protein 1, MLF1-Interacting Protein, CENP50, CENPU50, KSHV\nLatent Nuclear Antigen Interacting Protein 1, CENP-50, CENP-U, ICEN24.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174946275412,"sku":"PRO-1824","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174946308180,"sku":"PRO-1824","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174946340948,"sku":"PRO-1824","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cenpu-human-PRO-1824.png?v=1776680860"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_d3d5256e-7796-4694-9ffe-e4cecaaaf93f.png?v=1700646554","url":"https:\/\/prospecbio.com\/collections\/centromere-protein.oembed","provider":"prospecbio","version":"1.0","type":"link"}