{"title":"Calbindin","description":"\u003ch2 class=\"highlited\"\u003e\u003cspan\u003eAbout CALB \/ Calbindin:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003eWith Calbindin, the clue is in the name. The CALcium-BINDINg proteins come in a group of three distinctive elements: Calbindin 1, Calbindin 2 or Calretinin, and Calbindin 3 or S100G. Initially discovered by researchers in fractions of chicken intestines and the intestines and kidneys of mammals, CALB proteins were first described as vitamin D-dependent calcium-binding proteins.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCALB Function\u003c\/strong\u003e\u003cbr\u003eCALB proteins serve a unique role in helping to bind calcium in the micromolar range. Researchers have found a clear connection between vitamin D-deficiency and the reduced presence of CALB proteins.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCalbindin Structure\u003c\/strong\u003e\u003cbr\u003eCALB proteins exist in different sizes, with a molecular weight of approximately 9kDa and 28 kDa and 29 kDa. The subfamilies differ in their calcium-binding abilities and have different numbers of CA2+ binding structures or EF-hands.\u003cbr\u003eCalbindin 1 is found in bird intestines and mammal kidneys. It also appears in a number of cells, both neuronal and endocrine. It is a 28 kDa protein in humans, which is encoded by the gene CALB1. The protein has 6 EF-hands, 4 of which have active CA2+ binding abilities. It mediates calcium absorption.\u003cbr\u003eCalbindin 2 or Calretinin is primarily found in nervous tissues. It is a 29 kDa protein which counts 58% homology to Calbindin 1. It’s encoded by the gene CALB2. Structurally, the protein also consists of 6 EF-hands. CALB2 acts as a modulator of neuronal excitability. But it can also be used as a diagnostic marker for some human diseases and cancers.\u003cbr\u003eCalbindin 3 or S100G is primarily found in mammalian intestines, but it can also appear in the kidneys and uterus. S100G is encoded by the gene CALB3 in humans. It is a lighter protein with only 2 EF-hands. CALB3 mediates calcium transport across intestine cells.\u003c\/p\u003e","products":[{"product_id":"calb1-human","title":"CALB1 Human","description":"\u003cp\u003eCalbindin-1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCalbindin, Vitamin D-dependent calcium-binding protein, avian-type, Calbindin D28, D-28K, CALB1, CAB27, CALB, calbindin 1 28kDa.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43174610862164,"sku":"PRO-721","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174610894932,"sku":"PRO-721","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174610927700,"sku":"PRO-721","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-calb1-human-PRO-721.png?v=1776678851"},{"product_id":"calb1-rat","title":"CALB1 Rat","description":"\u003cp\u003eCalbindin-1 Rat Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCalbindin, Vitamin D-dependent calcium-binding protein, avian-type, Calbindin D28, D-28K, Spot 35 protein, Calb1, CaBP28K, MGC93326.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174611484756,"sku":"PRO-400","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174611517524,"sku":"PRO-400","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100µg","offer_id":43174611550292,"sku":"PRO-400","price":2500.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-calb1-rat-PRO-400.png?v=1776678856"},{"product_id":"calb2-human","title":"CALB2 Human","description":"\u003cp\u003eCalbindin-2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCalretinin, CR, CALB2, CAB29, CAL2, CaBP29K, 29 kDa calbindin.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174613516372,"sku":"PRO-401","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25µg","offer_id":43174613549140,"sku":"PRO-401","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174613581908,"sku":"PRO-401","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-calb2-human-PRO-401.png?v=1776678865"},{"product_id":"calmb2-mouse","title":"CALB2 Mouse","description":"\u003cp\u003eCalbindin-2 Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCalretinin, CR, Calb2, calbindin 2.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174614270036,"sku":"PRO-290","price":175.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174614302804,"sku":"PRO-290","price":270.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174614335572,"sku":"PRO-290","price":440.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-calmb2-mouse-PRO-290.png?v=1776678912"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_a56b1bc2-94c8-4484-a8d2-ecc38a227c55.png?v=1700646463","url":"https:\/\/prospecbio.com\/collections\/calbindin.oembed","provider":"prospecbio","version":"1.0","type":"link"}