{"title":"Cadherin","description":"\u003ch2 class=\"highlited\"\u003e\u003cspan\u003eAbout CDH \/ Cadherin:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003eA cadherin, or CDH, is a type of cell adhesion molecule that facilitates the formation of adherens junctions. These junctions play a critical role in enabling cells to bind to one another, hence CDH is also an important element in this process. There are numerous classes of cadherin molecules. Although there are believed to be over 100 types of CDHs, they are usually split into four groups: classical, protocadherins, desmosomal and unconventional\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCDH Function\u003c\/strong\u003e\u003cbr\u003eCDHs act as ligands and receptors for other molecules. They assist in the development of cells, specifically the separation of tissue layers and cellular migration. Different cadherins are required for different functions, hence they are present at varying stages of cell development.\u003cbr\u003eFollowing development, CDHs help to maintain tissue and cell structure, as well as playing a role in facilitating cellular movement.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCadherin Mechanism\u003c\/strong\u003e\u003cbr\u003eAdhesions between two cells are mediated by extracellular cadherin domains, while intracellular cytoplasmic tails are facilitated by multiple adaptors and signaling proteins. Collectively, these adaptors and signaling proteins are known as the cadherin adhesome.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCDH Interactions\u003c\/strong\u003e\u003cbr\u003eCadherins on one cell interact with cadherins on different cells to facilitate adhesions.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCadherin Structure\u003c\/strong\u003e\u003cbr\u003eSynthesized as polypeptides, cadherins are modified numerous times before they impact on cellular migration and adhesions. Typically, these peptides are around 720–750 amino acids long. Every CDH has a transmembrane component, which is comprised of a single chain glycoprotein repeats, and a small C-terminal cytoplasmic component, while the remaining protein is extra-cellular. In order to function, CDHs form two identical subunits: homodimers, which facilitate cell to cell adhesions.\u003c\/p\u003e","products":[{"product_id":"e-cadherin-human","title":"Cadherin-E Human","description":"\u003cp\u003eCadherin-E Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eEpithelial cadherin, E-cadherin, Uvomorulin, Cadherin-1, CAM 120\/80, CD324 antigen, CDH1, CDHE, UVO, ECAD, LCAM, Arc-1, CD324, Cadherin-E.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174607257684,"sku":"PRO-461","price":175.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174607290452,"sku":"PRO-461","price":270.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174607323220,"sku":"PRO-461","price":440.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-e-cadherin-human-PRO-461.png?v=1776683032"},{"product_id":"cdh1-human-hek","title":"CDH1 Human, HEK","description":"\u003cp\u003eE-Cadherin Human Recombinant, HEK\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eEpithelial cadherin, E-cadherin, Uvomorulin, Cadherin-1, CAM 120\/80, CD324 antigen, CDH1, CDHE, UVO, ECAD, LCAM, Arc-1, CD324, Cadherin-E.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"10µg","offer_id":43174896336980,"sku":"PRO-2197","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174896369748,"sku":"PRO-2197","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174896402516,"sku":"PRO-2197","price":2000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cdh1-human-hek-PRO-2197.png?v=1776680604"},{"product_id":"cdh1-human-sf9","title":"CDH1 Human, Sf9","description":"\u003cp\u003eE-Cadherin Human Recombinant, Sf9\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCadherin 1, Type 1, E-Cadherin, Cadherin 1, Type 1,\nE-Cadherin (Epithelial), Epithelial Cadherin, CAM 120\/80, Uvomorulin, CDHE, UVO,\nCalcium-Dependent Adhesion Protein, Epithelial, Cadherin 1, E-Cadherin\n(Epithelial), Cell-CAM 120\/80, CD324 Antigen, Arc-1, CD324, ECAD, LCAM, Cadherin-1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174897057876,"sku":"PRO-2265","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174897090644,"sku":"PRO-2265","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174897123412,"sku":"PRO-2265","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cdh1-human-sf9-PRO-2265.png?v=1776680609"},{"product_id":"cdh11-human","title":"CDH11 Human","description":"\u003cp\u003eCadherin 11 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCAD11, CDHOB, OB, OSF-4, Cadherin 11, Osteoblast cadherin, OB-cadherin.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174898171988,"sku":"PRO-1368","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174898204756,"sku":"PRO-1368","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174898237524,"sku":"PRO-1368","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cdh11-human-PRO-1368.png?v=1776680613"},{"product_id":"cdh2-human","title":"CDH2 Human","description":"\u003cp\u003eCadherin 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCadherin 2, Cadherin 2, Type 1, N-Cadherin (Neuronal), Neural Cadherin, N-Cadherin, CDw325, NCAD, CDHN, Calcium-Dependent Adhesion Protein, Neuronal, CD325 Antigen, N-Cadherin 1, Cadherin-2, CD325.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174899056724,"sku":"PRO-2455","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174899089492,"sku":"PRO-2455","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174899122260,"sku":"PRO-2455","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cdh2-human-PRO-2455.png?v=1776680618"},{"product_id":"cdh5-human","title":"CDH5 Human","description":"\u003cp\u003eCadherin 5 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCadherin 5, VE-Cadherin, Cadherin 5 Type 2 VE-Cadherin (Vascular Epithelium), CDH5, Cadherin 5 Type 2 (Vascular Endothelium), Vascular Endothelial Cadherin, 7B4 Antigen, Endothelial-Specific Cadherin, Cd144 Antigen, CD144 Antigen, Cadherin-5, CD144, 7B4.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174900269140,"sku":"PRO-2384","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174900301908,"sku":"PRO-2384","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174900334676,"sku":"PRO-2384","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cdh5-human-PRO-2384.png?v=1776680622"},{"product_id":"cdh5-mouse","title":"CDH5 Mouse","description":"\u003cp\u003eCadherin 5 Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCadherin-5,\nVascular endothelial cadherin, VE-cadherin, CD144, Cdh5.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"1µg","offer_id":43174901219412,"sku":"PRO-2244","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5µg","offer_id":43174901252180,"sku":"PRO-2244","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50µg","offer_id":43174901284948,"sku":"PRO-2244","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cdh5-mouse-PRO-2244.png?v=1776680627"},{"product_id":"cdhr5-mouse","title":"CDHR5 Mouse","description":"\u003cp\u003eCadherin Related Family Member 5 Mouse Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCadherin-related family member 5, Mu-protocadherin, Cdhr5, Mucdhl, Mupcdh, 1810074H01Rik, AI481143\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174902366292,"sku":"PRO-2647","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174902399060,"sku":"PRO-2647","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174902431828,"sku":"PRO-2647","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-cdhr5-mouse-PRO-2647.png?v=1776680631"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_010acbba-58b8-4c7f-9546-7359cfde2abe.png?v=1700646458","url":"https:\/\/prospecbio.com\/collections\/cadherin.oembed","provider":"prospecbio","version":"1.0","type":"link"}