{"title":"Bromodomain Containing","description":"\u003ch2 class=\"highlited\"\u003e\u003cspan\u003eAbout BRD \/ Bromodomain Containing:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003eA bromodomain, or BRD, is an amino acid protein domain that is capable of recognizing acetylated lysine residues and regulating gene expression. By reading these lysine residues, BRD carriy and translate the signal released by acetylated lysine residues into phenotypes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBRD Function\u003c\/strong\u003e\u003cbr\u003eBRD-containing proteins have multiple and varied functions. Bromodomain and extra-terminal domain (BET) is perhaps, the most well-known example of a BRD containing protein, although ASH1L also contains bromodomain.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBromodomain Containing Mechanism\u003c\/strong\u003e\u003cbr\u003eBRD proteins read acetylation marks on histones and convert the signal released into observable characteristics, or phenotypes. The presence of BRD is often necessary for chromatin remodeling and a protein-histone association to occur. Studies have shown that BRD translates deregulated cell acetylome into phenotypes associated with diseases, including cancer and multiple sclerosis (MS). Additionally, BRD-containing proteins have been found in oncogenic fusion proteins, which result from chromosomal rearrangements.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBRD Interactions\u003c\/strong\u003e\u003cbr\u003eBromodomain containing proteins have been shown to interact with a variety of materials, including ATAD2, BAZ2B, BPTF, BRD2, BRD3, BRD4, BRDT, BRD7, CECR2, CREBBP, EP300, GCN5, KIAA1240, all 6 single domains of PB1, PCAF, SMARCA2, SMARCA4, TAF1, TIF1a (PHD\/BRD), TRIM33A (PHD\/BRD).\u003cbr\u003eDue to the role of BRD in human diseases, BRD inhibitors are now being used in clinical trials to determine whether they can be used to effectively treat cancers.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBromodomain Containing Structure\u003c\/strong\u003e\u003cbr\u003eBRD presents as an all-α protein fold and features a bundle of four alpha helices. Each of these alpha helices are separated by loop regions. These loop regions are present in varying lengths and form a hydrophobic pocket, which facilitates the recognition of acetyl-lysine.\u003c\/p\u003e","products":[{"product_id":"brd1-human","title":"BRD1 Human","description":"\u003cp\u003eBromodomain Containing 1 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eBromodomain Containing 1, BRL, Bromodomain And PHD Finger-Containing Protein2, BR140-Like Protein, BRPF2, Bromodomain-Containing Protein 1, Bromodomain-Containing 1, BR140-Like, BRPF1, BRD1.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174501122132,"sku":"PRO-2117","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174501154900,"sku":"PRO-2117","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174501187668,"sku":"PRO-2117","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-brd1-human-PRO-2117.png?v=1776678271"},{"product_id":"brd2-human","title":"BRD2 Human","description":"\u003cp\u003eBromodomain Containing 2 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eBromodomain Containing 2, RING3, Really Interesting New\nGene 3 Protein, Bromodomain-Containing 2, O27.1.1, FSRG1, Female Sterile Homeotic-Related\nGene 1, Bromodomain-Containing Protein 2, KIAA9001, D6S113E, RNF3, FSH, NAT,\nBromodomain-containing protein 2 .\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174502105172,"sku":"PRO-2122","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174502137940,"sku":"PRO-2122","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174502170708,"sku":"PRO-2122","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-brd2-human-PRO-2122.png?v=1776678276"},{"product_id":"brd3-human","title":"BRD3 Human","description":"\u003cp\u003eBromodomain Containing 3  Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eORFX, RING3L, Bromodomain-containing protein 3, RING3-like\nprotein, KIAA0043, RING3L.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174502858836,"sku":"PRO-2143","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174502891604,"sku":"PRO-2143","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174502924372,"sku":"PRO-2143","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-brd3-human-PRO-2143.png?v=1776678281"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_e94cc5fc-a2df-41b4-be0d-694c98be504a.png?v=1700646441","url":"https:\/\/prospecbio.com\/collections\/bromodomain-containing.oembed","provider":"prospecbio","version":"1.0","type":"link"}