{"title":"Autophagy Related","description":"\u003ch2 class=\"highlited\" data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAbout ATG \/ Autophagy Related:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eAutophagy related protein, otherwise known as ATG, is involved in the regulation of dsDNA-induced innate immune responses, and is therefore a very important aspect to physiological immunity and wellbeing in all forms of life.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eATG Function \u0026amp; Structure\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eIt has been shown that atg9a regulates membrane trafficking involved in the movement of STING and dsDNA-induced production of type I IFNs. In general, these autophagosomes target and subsequently take over bacteria-containing vacuoles in a manner which is recognized as STING-dependent. As such, they also mediate the auto lysosomal degradation of invading bacteria.\u003cbr data-mce-fragment=\"1\"\u003eSimilarly, these autophagosomes also target and engulf ubiquitinated ASC, which in turn allows them to mediate auto lysosomal degradation of the AIM2-inflammasome, which is a key way to suppress the dsDNA-induced production of any inflammatory cytokines. As you might imagine, it is therefore an important part of fighting for immunity in many physiological systems.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eAutophagy Related Uses\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003eWhen we look at how these might be used therapeutically, the potential looks very strong. One good example is with DNA vaccination, a method for protecting a given organism against microbial infection and a range of cancers, using the genetic injection of dsDNA encoding, a protein antigen can then effectively stimulate the humoral and cellular immune responses. At the same time, such DNA vaccination of this kind causes an activation of the STING–TBK1 signaling axis, which in turn induces acquired immune responses. The result is the generation of antigen-specific T cells and the further production of antigen-specific antibodies.\u003c\/p\u003e","products":[{"product_id":"atg10-human","title":"ATG10 Human","description":"\u003cp\u003eAutophagy Related 10 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eAutophagy Related Protein 10, ATG10 Autophagy Related 10 Homolog (S. Cerevisiae), Ubiquitin-Like-Conjugating Enzyme ATG10, APG10 Autophagy 10-Like (S. Cerevisiae), APG10-Like, APG10L, Pp12616, DKFZP586I0418, FLJ13954, EC 6.3.2.-.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174282199124,"sku":"PRO-1234","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174282231892,"sku":"PRO-1234","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174282264660,"sku":"PRO-1234","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-atg10-human-PRO-1234.png?v=1776677093"},{"product_id":"atg3-human","title":"ATG3 Human","description":"\u003cp\u003eAutophagy Related 3 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eAPG3, APG3-LIKE, APG3L, PC3-96, Ubiquitin-like-conjugating enzyme ATG3, Autophagy-related protein 3, hApg3, PC3-96, ATG3.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174283870292,"sku":"PRO-1987","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174283903060,"sku":"PRO-1987","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174283935828,"sku":"PRO-1987","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-atg3-human-PRO-1987.png?v=1776677103"},{"product_id":"atg4b-human","title":"ATG4B Human","description":"\u003cp\u003eATG4 Autophagy Related 4 Homolog B Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eCysteine protease ATG4B, AUT-like 1 cysteine endopeptidasem, Autophagin-1, Autophagy-related cysteine endopeptidase 1, Autophagy-related protein 4 homolog B, hAPG4B, ATG4B, APG4B, AUTL1, KIAA0943.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"5µg","offer_id":43174284722260,"sku":"PRO-1048","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20µg","offer_id":43174284755028,"sku":"PRO-1048","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174284787796,"sku":"PRO-1048","price":3600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-atg4b-human-PRO-1048.png?v=1776677108"},{"product_id":"atg5-human","title":"ATG5 Human","description":"\u003cp\u003eAutophagy Related 5 Human Recombinant\u003c\/p\u003e\n\n\u003cdiv class=\"synonyms_hide\"\u003e\n  \u003cp\u003eAutophagy protein 5, APG5-like, Apoptosis-specific protein, ATG5, ASP, APG5, APG5L, hAPG5.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"prospecbio","offers":[{"title":"2µg","offer_id":43174285639764,"sku":"PRO-454","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10µg","offer_id":43174285672532,"sku":"PRO-454","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43174285705300,"sku":"PRO-454","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/files\/Prospecbio-atg5-human-PRO-454.png?v=1776677112"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0559\/3219\/0804\/collections\/Image_2a0fb5a5-7f61-404c-bae2-400261a9e19f.png?v=1700646391","url":"https:\/\/prospecbio.com\/collections\/autophagy-related.oembed","provider":"prospecbio","version":"1.0","type":"link"}