About CNOT / CCR4-NOT Transcription Complex:
The CCR4-NOT Transcription Complex is a complex protein with multiple units that regulates gene expression.
The acronym CCR4-NOT stands for Carbon Catabolite Repression—Negative On TATA-less. It is responsible for the mRNAs (Messenger RNA) life cycle (from the nucleus to the cytoplasm). The eukaryotes conserve the CCR4-NOT and ensure that the processes are well-defined by regulating them.
CNOT Mechanism
To achieve its functionality, the CCR4-NOT utilizes various repression, initiation, translation, and regulatory measures. Different processes are initiated during different periods to ensure an endless process loop. Its presence in the nucleus and cytoplasm enables the CCR4 to regulate the transcription and also translate the ribosomes.
CCR4-NOT Transcription Complex Structure
CCR4 consists of multiple units of conserved core proteins and scaffold proteins, which result in different functions of the protein in their different combinational amounts.
The extensive research of the CCR4's structures does not reveal the complex structure of the CCR4, but using the currently available designs makes it possible to work towards its gene expression functionality in the system.
CNOT Interactions
The interactions of the CCR4 with transcription factors will result in transcription activation or repression. It is dependent on the promoters in the yeast, receptors, inhibitors, and amount of eukaryotes.
These interactions will also affect the elongation and deletion of the mRNAs.
CCR4-NOT Transcription Complex Function
The CCR4 specializes in ensuring the mRNAs' production in the nucleus follows through the right processes, transcription initiation and elongation, quality control, mRNA export, and the decay and decompositions of the RNA. An insight into the functionality of the RA will give you a hint on the importance of CCR4.